{"product_id":"dao-enzyme-30000-hdu","title":"RetzlerRx® DAO Enzyme 30,000 HDU | Dietary Histamine Support","description":"\u003csection style=\"max-width: 900px; margin: 0 auto;\"\u003e\n\n  \u003cdiv style=\"border: 1px solid #e5e7eb; border-radius: 14px; padding: 18px; background: #fafafa; margin-bottom: 25px;\"\u003e\n    \u003cstrong\u003eAI Overview:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\n    RetzlerRx® DAO Enzyme provides \u003cstrong\u003e30,000 Histamine Degrading Units (HDU) of diamine oxidase per capsule\u003c\/strong\u003e. DAO is concentrated in the intestinal mucosa, where it helps metabolize histamine from food before much of that histamine is absorbed. Taken shortly before a meal, supplemental DAO provides targeted digestive support when dietary histamine is a concern.*\n  \u003c\/div\u003e\n\n  \u003cp\u003e\u003cstrong\u003eRetzlerRx® DAO Enzyme 30,000 HDU\u003c\/strong\u003e is a concentrated DAO formula designed to support the metabolism of \u003cstrong\u003efood-derived histamine within the gastrointestinal tract\u003c\/strong\u003e.* Each capsule contains 4.2 mg of porcine kidney extract (DAOgest®), providing \u003cstrong\u003e30,000 HDU of diamine oxidase\u003c\/strong\u003e.\u003c\/p\u003e\n\n  \u003cp\u003eDAO has a specific physiological role. It is highly expressed in the intestinal mucosa, particularly in the small intestine, where it helps metabolize histamine present in food before that histamine moves into the circulation. Supplemental DAO is therefore generally used shortly before eating rather than as a general-purpose systemic histamine supplement.*\u003c\/p\u003e\n\n  \u003cdiv style=\"border-left: 4px solid #222; background: #f7f7f7; padding: 20px 22px; margin: 28px 0;\"\u003e\n    \u003ch2 style=\"margin-top: 0;\"\u003eOne-Minute Read\u003c\/h2\u003e\n\n    \u003cp\u003eHistamine is a normal signaling molecule involved in immune activity, digestion, nervous-system signaling and blood-vessel regulation. It is also present in food. Aged cheeses, cured meats, fermented foods, wine, beer and certain fish can contain substantially more histamine than many freshly prepared foods.\u003c\/p\u003e\n\n    \u003cp\u003eDiamine oxidase, usually shortened to DAO, is one of the body's principal enzymes for handling this dietary histamine. DAO is concentrated in the intestinal lining, where it helps break down histamine before much of it is absorbed.\u003c\/p\u003e\n\n    \u003cp\u003eRetzlerRx® DAO Enzyme provides \u003cstrong\u003e30,000 HDU of DAO in one capsule\u003c\/strong\u003e and is designed to be taken shortly before a meal. Its role is intentionally narrow: supporting the metabolism of histamine arriving through food.* DAO does not block histamine receptors throughout the body, and it should not be confused with an antihistamine medication or treatment for an IgE-mediated food allergy.\u003c\/p\u003e\n\n    \u003cp\u003eFor people who notice a consistent relationship between certain meals and symptoms, supplemental DAO can be one practical tool while diet, gastrointestinal health and the broader clinical pattern are considered.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"padding: 16px 18px; border: 1px solid #e5e5e5; margin: 22px 0; background: #ffffff;\"\u003e\n    \u003cstrong\u003eBest For\u003c\/strong\u003e\n    \u003cul style=\"margin-bottom: 0;\"\u003e\n      \u003cli\u003eSupporting the breakdown of dietary histamine before absorption.*\u003c\/li\u003e\n      \u003cli\u003eSupporting digestive comfort around histamine-containing foods.*\u003c\/li\u003e\n      \u003cli\u003eProviding additional DAO enzyme activity around meals.*\u003c\/li\u003e\n      \u003cli\u003eAdults who notice a reproducible sensitivity to histamine-rich foods.*\u003c\/li\u003e\n      \u003cli\u003eThose looking for a higher-activity 30,000 HDU DAO capsule.*\u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eWhat Is Diamine Oxidase?\u003c\/h2\u003e\n\n  \u003cp\u003e\u003cstrong\u003eDiamine oxidase (DAO)\u003c\/strong\u003e is an enzyme involved in the metabolism of extracellular histamine. It is highly expressed in the intestinal mucosa and is particularly active in the small intestine.\u003c\/p\u003e\n\n  \u003cp\u003eWithin the digestive tract, DAO contributes to an enzymatic barrier between histamine contained in food and the systemic circulation. By metabolizing histamine while it is still in the intestinal lumen, DAO helps limit the amount of dietary histamine available for absorption.*\u003c\/p\u003e\n\n  \u003cp\u003eDAO is also found in other tissues, including the colon, kidneys, thymus and placenta, but its intestinal activity is especially relevant when discussing food-derived histamine.\u003c\/p\u003e\n\n  \u003ch2\u003eHistamine Is Not Inherently a Problem\u003c\/h2\u003e\n\n  \u003cp\u003eHistamine is a normal biogenic amine made from the amino acid histidine. The body uses it as an immune mediator, neurotransmitter and local signaling molecule. Through its different receptors, histamine participates in vascular regulation, gastric physiology, smooth-muscle activity and sensory signaling.\u003c\/p\u003e\n\n  \u003cp\u003eThe goal of DAO supplementation is therefore not to eliminate histamine from the body. Its intended role is much more specific: supporting the metabolism of histamine encountered through food within the gastrointestinal tract.*\u003c\/p\u003e\n\n  \u003ch2\u003eWhere Dietary Histamine Comes From\u003c\/h2\u003e\n\n  \u003cp\u003eHistamine can accumulate in food when microorganisms convert histidine into histamine. Fermentation, aging, curing, processing and storage can all influence how much histamine a food contains.\u003c\/p\u003e\n\n  \u003cp\u003eFoods commonly associated with higher dietary histamine exposure include:\u003c\/p\u003e\n\n  \u003cul\u003e\n    \u003cli\u003eAged and matured cheeses\u003c\/li\u003e\n    \u003cli\u003eCured and processed meats\u003c\/li\u003e\n    \u003cli\u003eFermented foods\u003c\/li\u003e\n    \u003cli\u003eWine and beer\u003c\/li\u003e\n    \u003cli\u003eCertain fish and seafood\u003c\/li\u003e\n    \u003cli\u003eFoods stored as leftovers for extended periods\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003cp\u003eThis does not mean these foods are unhealthy or that everyone should avoid them. Histamine content varies from one food and preparation method to another, and individual tolerance varies considerably.\u003c\/p\u003e\n\n  \u003ch2\u003e30,000 HDU Per Capsule\u003c\/h2\u003e\n\n  \u003cp\u003eDAO supplements are generally described according to \u003cstrong\u003eHistamine Degrading Units, or HDU\u003c\/strong\u003e. HDU describes enzyme activity rather than simply reporting the physical weight of the ingredient.\u003c\/p\u003e\n\n  \u003cdiv style=\"border: 1px solid #e5e7eb; border-radius: 12px; padding: 20px; margin: 22px 0;\"\u003e\n    \u003cp style=\"margin-top: 0;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 1 Capsule\u003cbr\u003e\n    \u003cstrong\u003eServings Per Container:\u003c\/strong\u003e 60\u003c\/p\u003e\n\n    \u003cp\u003e\u003cstrong\u003ePorcine Kidney Extract (DAOgest®): 4.2 mg\u003c\/strong\u003e\u003cbr\u003e\n    Providing \u003cstrong\u003e30,000 HDU Diamine Oxidase (DAO)\u003c\/strong\u003e\u003c\/p\u003e\n\n    \u003cp style=\"margin-bottom: 0;\"\u003e\u003cem\u003eDaily Value not established.\u003c\/em\u003e\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cp\u003eThe 30,000 HDU activity level makes this a concentrated option for individuals who want targeted DAO support around meals.*\u003c\/p\u003e\n\n  \u003ch2\u003eWhy Timing Matters\u003c\/h2\u003e\n\n  \u003cp\u003eSupplemental DAO is intended to be present in the gastrointestinal tract when dietary histamine arrives. For that reason, timing the capsule close to a meal is consistent with the way the enzyme is intended to function.\u003c\/p\u003e\n\n  \u003cp\u003e\u003cstrong\u003eSuggested Use:\u003c\/strong\u003e Take \u003cstrong\u003e1 capsule approximately 15 minutes before a meal\u003c\/strong\u003e, or as recommended by your health care professional.\u003c\/p\u003e\n\n  \u003ch2\u003eDAO Is Not the Same as an Antihistamine\u003c\/h2\u003e\n\n  \u003cp\u003eAntihistamine medications generally work by blocking histamine receptors. Supplemental DAO works differently. It is an enzyme intended to help metabolize histamine within the digestive tract.*\u003c\/p\u003e\n\n  \u003cp\u003eThis distinction is important because many symptoms commonly attributed to “histamine” can have other causes. Headache, flushing, nasal symptoms, itching and gastrointestinal discomfort are not specific to impaired dietary histamine metabolism.\u003c\/p\u003e\n\n  \u003cp\u003eA response to DAO may be useful information, but it should not automatically become a diagnosis.\u003c\/p\u003e\n\n  \u003ch2\u003eHistamine Intolerance Is More Complicated Than a Food List\u003c\/h2\u003e\n\n  \u003cp\u003eThe term \u003cstrong\u003ehistamine intolerance\u003c\/strong\u003e is generally used when symptoms appear to result from an imbalance between dietary histamine exposure and the body's ability to metabolize it. Reduced intestinal DAO activity is one proposed contributor.\u003c\/p\u003e\n\n  \u003cp\u003eThere is no single symptom or laboratory test that establishes histamine intolerance in every patient. Dietary exposure, intestinal health, medications, alcohol intake, genetics and other medical conditions may all influence how someone responds.\u003c\/p\u003e\n\n  \u003cp\u003eThis is one reason we prefer targeted support over indefinite food restriction. When histamine-rich foods appear to cause a reproducible problem, temporary dietary modification, careful reintroduction and appropriate clinical evaluation can be more informative than progressively eliminating foods without understanding the pattern.\u003c\/p\u003e\n\n  \u003ch2\u003eDAO and Food Allergy Are Different\u003c\/h2\u003e\n\n  \u003cp\u003eDAO supplementation should not be used to prevent or treat an \u003cstrong\u003eIgE-mediated food allergy\u003c\/strong\u003e. Food allergy involves a different immune mechanism and can produce severe or life-threatening reactions.\u003c\/p\u003e\n\n  \u003cp\u003eAnyone experiencing throat tightness, facial or tongue swelling, wheezing, difficulty breathing, faintness or a history of anaphylaxis requires appropriate medical evaluation. DAO should never be used as protection before deliberately consuming a known allergenic food.\u003c\/p\u003e\n\n  \u003ch2\u003eDAO and Mast Cell Disorders Are Also Different\u003c\/h2\u003e\n\n  \u003cp\u003eMast cells can release histamine produced within the body. Oral DAO, by contrast, is primarily intended to support metabolism of histamine encountered within the gastrointestinal tract.*\u003c\/p\u003e\n\n  \u003cp\u003eSymptoms can overlap, but a mast-cell disorder and impaired handling of dietary histamine are not interchangeable diagnoses. Persistent or unexplained symptoms deserve appropriate medical evaluation rather than assuming that increasing DAO intake will address the underlying problem.\u003c\/p\u003e\n\n  \u003ch2\u003eDAO Within a Broader Gut-Health Strategy\u003c\/h2\u003e\n\n  \u003cp\u003eDAO can be useful when the immediate issue is dietary histamine, but intestinal physiology extends well beyond a single enzyme. The condition of the intestinal mucosa, microbiome, barrier function, gastrointestinal motility, diet and medication exposure can all influence how someone responds to food.\u003c\/p\u003e\n\n  \u003cp\u003eFor a broader clinical discussion, read the HormoneSynergy® \u003ca href=\"\/blogs\/longevity-anti-aging-functional-wellness-usa\/gut-health-microbiome-longevity-medicine\"\u003e\u003cstrong\u003eGut Health and the Microbiome: How the Gut Influences Metabolism, Immunity, and Longevity\u003c\/strong\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\n  \u003cp\u003eFor our broader approach to nutritional supplementation, read \u003ca href=\"\/blogs\/longevity-anti-aging-functional-wellness-usa\/supplements-longevity-medicine-what-helps-hype-stop\"\u003e\u003cstrong\u003eSupplements in Longevity Medicine: What Helps, What Is Hype, and Where We Stop\u003c\/strong\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\n  \u003ch2\u003eDAO Enzyme 30,000 HDU or Hist Arrest?\u003c\/h2\u003e\n\n  \u003cp\u003eHormoneSynergy® carries two RetzlerRx® DAO options for people seeking targeted support around dietary histamine.*\u003c\/p\u003e\n\n  \u003cp\u003e\u003cstrong\u003eRetzlerRx® DAO Enzyme\u003c\/strong\u003e provides \u003cstrong\u003e30,000 HDU per capsule\u003c\/strong\u003e from porcine kidney extract (DAOgest®). It is the higher-activity option and is intended to be taken approximately 15 minutes before a meal.*\u003c\/p\u003e\n\n  \u003cp\u003e\u003ca href=\"\/products\/diamine-oxidase-for-histamine-intolerance\"\u003e\u003cstrong\u003eRetzlerRx® Hist Arrest\u003c\/strong\u003e\u003c\/a\u003e provides \u003cstrong\u003e20,000 HDU per tablet\u003c\/strong\u003e and offers another option for targeted DAO support around meals.*\u003c\/p\u003e\n\n  \u003cp\u003eYou can also browse the HormoneSynergy® \u003ca href=\"\/collections\/histamine-probiotics-and-gut-health\"\u003e\u003cstrong\u003eGut Health, Histamine \u0026amp; Probiotics Collection\u003c\/strong\u003e\u003c\/a\u003e for additional digestive and gut-barrier support options.\u003c\/p\u003e\n\n  \u003ch2\u003eWho May Consider DAO Enzyme 30,000 HDU?\u003c\/h2\u003e\n\n  \u003cp\u003eDAO supplementation may be considered by adults who notice a reasonably consistent relationship between histamine-rich foods and digestive or other food-associated reactions, particularly when the goal is to support intestinal metabolism of dietary histamine.*\u003c\/p\u003e\n\n  \u003cp\u003eBecause this product uses \u003cstrong\u003eporcine kidney extract\u003c\/strong\u003e, it is not suitable for vegetarian or vegan diets and may not be appropriate for individuals who avoid pork-derived ingredients.\u003c\/p\u003e\n\n  \u003ch2\u003eSuggested Use\u003c\/h2\u003e\n\n  \u003cp\u003eTake \u003cstrong\u003e1 capsule approximately 15 minutes before a meal\u003c\/strong\u003e, or as recommended by your health care professional.\u003c\/p\u003e\n\n  \u003cp\u003eDAO is intended for use in relation to dietary histamine exposure rather than as a substitute for identifying persistent or medically significant food reactions.\u003c\/p\u003e\n\n  \u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\n  \u003ch3\u003eWhat does RetzlerRx® DAO Enzyme do?\u003c\/h3\u003e\n  \u003cp\u003eIt provides supplemental diamine oxidase to support the breakdown of histamine from food within the gastrointestinal tract before much of that histamine is absorbed.*\u003c\/p\u003e\n\n  \u003ch3\u003eHow much DAO is in each capsule?\u003c\/h3\u003e\n  \u003cp\u003eEach capsule provides \u003cstrong\u003e30,000 Histamine Degrading Units (HDU)\u003c\/strong\u003e from 4.2 mg of porcine kidney extract (DAOgest®).\u003c\/p\u003e\n\n  \u003ch3\u003eHow many capsules are in each bottle?\u003c\/h3\u003e\n  \u003cp\u003eEach bottle contains \u003cstrong\u003e60 capsules\u003c\/strong\u003e.\u003c\/p\u003e\n\n  \u003ch3\u003eWhen should I take DAO Enzyme?\u003c\/h3\u003e\n  \u003cp\u003eThe suggested use is one capsule approximately \u003cstrong\u003e15 minutes before a meal\u003c\/strong\u003e, or as recommended by your health care professional.\u003c\/p\u003e\n\n  \u003ch3\u003eDoes DAO lower histamine throughout the entire body?\u003c\/h3\u003e\n  \u003cp\u003eOral DAO is primarily intended to support metabolism of dietary histamine within the gastrointestinal tract.* It should not be viewed as a systemic antihistamine.\u003c\/p\u003e\n\n  \u003ch3\u003eIs DAO the same as an antihistamine medication?\u003c\/h3\u003e\n  \u003cp\u003eNo. Antihistamine medications generally block histamine receptors. DAO is an enzyme that helps metabolize histamine within the digestive tract.\u003c\/p\u003e\n\n  \u003ch3\u003eCan DAO treat a food allergy?\u003c\/h3\u003e\n  \u003cp\u003eNo. DAO supplementation should not be used to treat or prevent an IgE-mediated food allergy or anaphylaxis.\u003c\/p\u003e\n\n  \u003ch3\u003eCan DAO be used for environmental allergies?\u003c\/h3\u003e\n  \u003cp\u003eThis product is formulated around the metabolism of \u003cstrong\u003efood-derived histamine within the gastrointestinal tract\u003c\/strong\u003e.* It should not be presented as a treatment for pollen, animal dander or other environmental allergies.\u003c\/p\u003e\n\n  \u003ch3\u003eWhat is the difference between DAO Enzyme 30,000 HDU and Hist Arrest?\u003c\/h3\u003e\n  \u003cp\u003eDAO Enzyme provides \u003cstrong\u003e30,000 HDU per capsule\u003c\/strong\u003e from porcine kidney extract (DAOgest®). RetzlerRx® Hist Arrest provides \u003cstrong\u003e20,000 HDU per tablet\u003c\/strong\u003e. Both are intended to support the metabolism of dietary histamine within the digestive tract.*\u003c\/p\u003e\n\n  \u003ch3\u003eIs DAO Enzyme 30,000 HDU vegetarian?\u003c\/h3\u003e\n  \u003cp\u003eNo. The DAO ingredient is derived from porcine kidney extract.\u003c\/p\u003e\n\n  \u003chr style=\"margin: 34px 0; border: 0; border-top: 1px solid #e5e7eb;\"\u003e\n\n  \u003cp style=\"font-size: 13px;\"\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003c\/section\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What does RetzlerRx DAO Enzyme do?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"RetzlerRx DAO Enzyme provides supplemental diamine oxidase to support the breakdown of histamine from food within the gastrointestinal tract before much of that histamine is absorbed.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How much DAO is in each capsule?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Each capsule provides 30,000 Histamine Degrading Units (HDU) from 4.2 mg of porcine kidney extract (DAOgest).\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How many capsules are in each bottle?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Each bottle contains 60 capsules.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"When should I take DAO Enzyme?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"The suggested use is one capsule approximately 15 minutes before a meal, or as recommended by your health care professional.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Does DAO lower histamine throughout the entire body?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Oral DAO is primarily intended to support metabolism of dietary histamine within the gastrointestinal tract and should not be viewed as a systemic antihistamine.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is DAO the same as an antihistamine medication?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. Antihistamine medications generally block histamine receptors. DAO is an enzyme that helps metabolize histamine within the digestive tract.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Can DAO treat a food allergy?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. DAO supplementation should not be used to treat or prevent an IgE-mediated food allergy or anaphylaxis.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Can DAO be used for environmental allergies?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"DAO Enzyme is formulated around the metabolism of food-derived histamine within the gastrointestinal tract and should not be presented as a treatment for environmental allergies.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is the difference between DAO Enzyme 30,000 HDU and Hist Arrest?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"DAO Enzyme provides 30,000 HDU per capsule from porcine kidney extract. RetzlerRx Hist Arrest provides 20,000 HDU per tablet. Both are intended to support metabolism of dietary histamine within the digestive tract.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is DAO Enzyme 30,000 HDU vegetarian?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. The DAO ingredient is derived from porcine kidney extract.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"HormoneSynergy","offers":[{"title":"Default Title","offer_id":45752078205037,"sku":null,"price":57.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/9721\/files\/retzlerrx-dao-enzyme-30000-hdu-histamine-support.png?v=1788223189","url":"https:\/\/hormonesynergy.com\/products\/dao-enzyme-30000-hdu","provider":"HormoneSynergy","version":"1.0","type":"link"}