{"product_id":"https-hormonesynergy-com-products-pendulum-metabolic-daily-probiotic","title":"Pendulum® Metabolic Daily PRO Has been discountinued.","description":"\u003csection style=\"max-width:900px; margin:0 auto;\"\u003e\n\n\u003cdiv style=\"border:1px solid #e5e5e5; padding:18px; background:#fafafa; margin-bottom:25px;\"\u003e\n\u003cstrong\u003eMetabolic Daily PRO Has Been Discontinued\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\nPendulum® Metabolic Daily PRO is no longer available. If you are looking for daily gut microbiome and metabolic-health support, Pendulum's standard \u003cstrong\u003eMetabolic Daily\u003c\/strong\u003e remains available and contains the same five-organism probiotic ecosystem, including live \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e.\u003cbr\u003e\u003cbr\u003e\n\u003ca href=\"https:\/\/hormonesynergy.com\/products\/pendulum-metabolic-daily-probiotic\"\u003e\u003cstrong\u003eView Pendulum® Metabolic Daily →\u003c\/strong\u003e\u003c\/a\u003e\n\u003c\/div\u003e\n\n\u003cp\u003e\u003cstrong\u003ePendulum® Metabolic Daily PRO\u003c\/strong\u003e was the higher-potency professional version of Pendulum's five-strain Metabolic Daily probiotic. Each capsule provided \u003cstrong\u003e1 billion AFU\u003c\/strong\u003e of live probiotic organisms, including \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e, compared with \u003cstrong\u003e300 million AFU per capsule\u003c\/strong\u003e in the standard retail Metabolic Daily formula.\u003c\/p\u003e\n\n\u003cp\u003eBoth formulations use the same five-organism microbiome strategy. The principal difference was the higher total labeled potency of the discontinued PRO formulation.\u003c\/p\u003e\n\n\u003cp\u003eThis page is retained for educational purposes and for customers who previously used Metabolic Daily PRO.\u003c\/p\u003e\n\n\u003ch2\u003eMetabolic Daily PRO vs. Metabolic Daily\u003c\/h2\u003e\n\n\u003cp\u003eThe two products contain the \u003cstrong\u003esame five probiotic organisms\u003c\/strong\u003e, but they are different finished formulations.\u003c\/p\u003e\n\n\u003cdiv style=\"overflow-x:auto; margin:20px 0;\"\u003e\n\u003ctable style=\"width:100%; border-collapse:collapse; min-width:600px;\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; padding:10px; border-bottom:2px solid #ddd;\"\u003eFeature\u003c\/th\u003e\n\u003cth style=\"text-align:left; padding:10px; border-bottom:2px solid #ddd;\"\u003eMetabolic Daily PRO\u003c\/th\u003e\n\u003cth style=\"text-align:left; padding:10px; border-bottom:2px solid #ddd;\"\u003eMetabolic Daily\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e\u003cstrong\u003eStatus\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e\u003cstrong\u003eDiscontinued\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e\u003cstrong\u003eAvailable\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e\u003cstrong\u003eTotal Potency\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e1 billion AFU\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e300 million AFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e\u003cstrong\u003eServing\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e1 capsule daily\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e1 capsule daily\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003e\u003cstrong\u003eOrganisms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003eFive-strain ecosystem\u003c\/td\u003e\n\u003ctd style=\"padding:10px; border-bottom:1px solid #e5e5e5;\"\u003eSame five-strain ecosystem\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px;\"\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding:10px;\"\u003eProfessional, 30 capsules\u003c\/td\u003e\n\u003ctd style=\"padding:10px;\"\u003eRetail, 30 and 90 capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\n\u003cp\u003eMetabolic Daily PRO provided approximately \u003cstrong\u003e3.3 times the total labeled AFU per capsule\u003c\/strong\u003e. That did not mean it had been shown to produce 3.3 times the clinical effect. Probiotic response does not scale that neatly, and the two finished products were not compared head-to-head in a clinical outcomes trial.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eLooking for the current formulation?\u003c\/strong\u003e See \u003ca href=\"https:\/\/hormonesynergy.com\/products\/pendulum-metabolic-daily-probiotic\"\u003ePendulum® Metabolic Daily\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eThe Five-Organism Formula\u003c\/h2\u003e\n\n\u003cp\u003eMetabolic Daily PRO contained a \u003cstrong\u003e1 billion AFU probiotic blend\u003c\/strong\u003e consisting of:\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cem\u003eClostridium butyricum\u003c\/em\u003e WB-STR-0006\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cem\u003eClostridium beijerinckii\u003c\/em\u003e WB-STR-0005\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cem\u003eBifidobacterium infantis\u003c\/em\u003e\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cem\u003eAnaerobutyricum hallii\u003c\/em\u003e WB-STR-0008\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e WB-STR-0001\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eThe value of the formula was not simply that five organisms were present. Pendulum designed these organisms around different functions within the gut microbiome, including fermentation, microbial cross-feeding, interaction with the intestinal mucus environment, and short-chain fatty acid biology.*\u003c\/p\u003e\n\n\u003ch2\u003eLive Akkermansia muciniphila\u003c\/h2\u003e\n\n\u003cp\u003e\u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e has become one of the more closely studied organisms in metabolic microbiome research. It naturally lives near the intestinal mucus layer, placing it at an important interface between the gut microbiota and intestinal epithelium.\u003c\/p\u003e\n\n\u003cp\u003eHuman research on Akkermansia has expanded considerably in recent years, including studies examining insulin sensitivity, metabolic physiology, body composition, and weight maintenance. The results remain formulation- and population-specific, but Akkermansia is no longer interesting only because of observational microbiome associations.\u003c\/p\u003e\n\n\u003cp\u003eMetabolic Daily PRO contained Pendulum's \u003cstrong\u003elive \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e WB-STR-0001\u003c\/strong\u003e. Pendulum's standard \u003ca href=\"https:\/\/hormonesynergy.com\/products\/pendulum-metabolic-daily-probiotic\"\u003eMetabolic Daily\u003c\/a\u003e also contains live \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e as part of its five-organism formula.\u003c\/p\u003e\n\n\u003ch2\u003eButyrate and Microbial Cross-Feeding\u003c\/h2\u003e\n\n\u003cp\u003eSeveral organisms in the Metabolic Daily formula participate directly or indirectly in production of short-chain fatty acids such as \u003cstrong\u003ebutyrate\u003c\/strong\u003e.\u003c\/p\u003e\n\n\u003cp\u003eButyrate is produced when intestinal bacteria ferment dietary substrates. Colon cells use it as an important energy source, and it also participates in signaling related to intestinal barrier integrity, immune regulation, and metabolic physiology.*\u003c\/p\u003e\n\n\u003cp\u003eEqually important is \u003cstrong\u003emicrobial cross-feeding\u003c\/strong\u003e. One organism can produce metabolites that become fuel for another. This is how an intestinal ecosystem actually operates, and it is one reason the functional relationship between strains can be more informative than simply comparing probiotic counts.\u003c\/p\u003e\n\n\u003ch2\u003eWhy the Gut–Metabolism Connection Matters\u003c\/h2\u003e\n\n\u003cp\u003eThe microbiome participates in digestion, fermentation, bile acid metabolism, intestinal barrier function, immune signaling, and production of microbial metabolites that communicate with the rest of the body.\u003c\/p\u003e\n\n\u003cp\u003eShort-chain fatty acids can also interact with intestinal receptors and enteroendocrine cells involved in metabolic signaling. This is one reason the relationship between the microbiome, glucose physiology, appetite signaling, and endogenous hormones such as GLP-1 has become an active area of research.\u003c\/p\u003e\n\n\u003cp\u003ePendulum's metabolic microbiome formulations are designed around these normal microbial and metabolic pathways.* They are not substitutes for medication or medical treatment for diabetes, obesity, insulin resistance, or another metabolic condition.\u003c\/p\u003e\n\n\u003ch2\u003eWhat Does the Clinical Research Show?\u003c\/h2\u003e\n\n\u003cp\u003ePendulum has published randomized human research using a closely related five-organism formulation in adults with type 2 diabetes. That research demonstrated improvements in post-meal glucose control and provided evidence that this type of deliberately assembled microbial ecosystem can alter metabolic physiology and microbial metabolites in humans.\u003c\/p\u003e\n\n\u003cp\u003eThe distinction between the research formulation and commercial Pendulum products remains important. The earlier clinical formulation was not identical to either today's standard Metabolic Daily or the discontinued Metabolic Daily PRO, and those results should not be interpreted as proof that either finished product lowers A1C or treats diabetes.\u003c\/p\u003e\n\n\u003cp\u003eThe research is nevertheless relevant because the five bacterial species overlap and support the biological rationale behind Pendulum's metabolic microbiome platform.\u003c\/p\u003e\n\n\u003cp\u003eFor a deeper look at the research and the formulations, see \u003ca href=\"https:\/\/hormonesynergy.com\/blogs\/longevity-anti-aging-functional-wellness-usa\/pendulum-metabolic-daily-pro-live-akkermansia\"\u003ePendulum® Metabolic Daily and Metabolic Daily PRO: Live Akkermansia, Butyrate, and the 5-Strain Microbiome\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eLooking for Metabolic Daily PRO?\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003eMetabolic Daily PRO has been discontinued.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eFor those interested in Pendulum's five-organism daily microbiome formula, the standard \u003cstrong\u003ePendulum® Metabolic Daily\u003c\/strong\u003e remains available. It contains the same five bacterial species used in Metabolic Daily PRO, including live \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e, at a lower total labeled AFU per capsule.\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"https:\/\/hormonesynergy.com\/products\/pendulum-metabolic-daily-probiotic\"\u003e\u003cstrong\u003eShop Pendulum® Metabolic Daily →\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\n\u003ch3\u003eHas Pendulum Metabolic Daily PRO been discontinued?\u003c\/h3\u003e\n\u003cp\u003eYes. Pendulum® Metabolic Daily PRO has been discontinued and is no longer available through HormoneSynergy®. Pendulum's standard \u003ca href=\"https:\/\/hormonesynergy.com\/products\/pendulum-metabolic-daily-probiotic\"\u003eMetabolic Daily\u003c\/a\u003e remains available.\u003c\/p\u003e\n\n\u003ch3\u003eWhat can I use instead of Metabolic Daily PRO?\u003c\/h3\u003e\n\u003cp\u003ePendulum® Metabolic Daily is the closest current option. It contains the same five-organism probiotic ecosystem, including live \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e, although it provides a lower total labeled AFU per capsule than the discontinued PRO formulation.\u003c\/p\u003e\n\n\u003ch3\u003eHow was Metabolic Daily PRO different from regular Metabolic Daily?\u003c\/h3\u003e\n\u003cp\u003eBoth contain the same five organisms. Metabolic Daily PRO provided 1 billion total AFU per capsule, while standard retail Metabolic Daily provides 300 million AFU per capsule.\u003c\/p\u003e\n\n\u003ch3\u003eWas Metabolic Daily PRO three times more effective than regular Metabolic Daily?\u003c\/h3\u003e\n\u003cp\u003eThat was never established. PRO provided approximately 3.3 times the labeled total AFU, but the products were not compared head-to-head in a clinical outcomes trial, and probiotic effects do not necessarily increase in direct proportion to AFU.\u003c\/p\u003e\n\n\u003ch3\u003eDid Metabolic Daily PRO contain live Akkermansia?\u003c\/h3\u003e\n\u003cp\u003eYes. Metabolic Daily PRO contained live \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e WB-STR-0001. Standard Metabolic Daily also contains live \u003cem\u003eAkkermansia muciniphila\u003c\/em\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhat are AFUs?\u003c\/h3\u003e\n\u003cp\u003eAFU stands for Active Fluorescent Units, a method used to quantify viable bacterial cells.\u003c\/p\u003e\n\n\u003ch3\u003eWhat is butyrate and why is it relevant?\u003c\/h3\u003e\n\u003cp\u003eButyrate is a short-chain fatty acid produced through intestinal bacterial fermentation. It serves as an important energy source for colon cells and participates in normal gut barrier, immune, and metabolic signaling.*\u003c\/p\u003e\n\n\u003ch3\u003eWas Metabolic Daily PRO clinically shown to lower A1C?\u003c\/h3\u003e\n\u003cp\u003eNo. Metabolic Daily PRO itself was not established in a randomized clinical trial as an A1C-lowering treatment. Pendulum has published human research using a closely related five-organism formulation, but those findings should not be treated as direct proof of an A1C effect from the discontinued PRO product or from standard Metabolic Daily.\u003c\/p\u003e\n\n\u003cp style=\"font-size:0.92em; margin-top:30px;\"\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Has Pendulum Metabolic Daily PRO been discontinued?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes. Pendulum Metabolic Daily PRO has been discontinued and is no longer available through HormoneSynergy. Pendulum's standard Metabolic Daily remains available.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What can I use instead of Metabolic Daily PRO?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Pendulum Metabolic Daily is the closest current option. It contains the same five-organism probiotic ecosystem, including live Akkermansia muciniphila, although it provides a lower total labeled AFU per capsule than the discontinued PRO formulation.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How was Metabolic Daily PRO different from regular Metabolic Daily?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Both contain the same five organisms. Metabolic Daily PRO provided 1 billion total AFU per capsule, while standard retail Metabolic Daily provides 300 million AFU per capsule.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Was Metabolic Daily PRO three times more effective than regular Metabolic Daily?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"That was not established. PRO provided approximately 3.3 times the labeled total AFU, but the products were not compared head-to-head in a clinical outcomes trial.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Did Metabolic Daily PRO contain live Akkermansia?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes. Metabolic Daily PRO contained live Akkermansia muciniphila WB-STR-0001. Standard Metabolic Daily also contains live Akkermansia muciniphila.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are AFUs?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"AFU stands for Active Fluorescent Units, a method used to quantify viable bacterial cells.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is butyrate and why is it relevant?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Butyrate is a short-chain fatty acid produced through intestinal bacterial fermentation. It serves as an important energy source for colon cells and participates in normal gut barrier, immune, and metabolic signaling.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Was Metabolic Daily PRO clinically shown to lower A1C?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. Metabolic Daily PRO itself was not established in a randomized clinical trial as an A1C-lowering treatment.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e\n\n\u003c\/section\u003e","brand":"HormoneSynergy","offers":[{"title":"Default Title","offer_id":42678078832749,"sku":null,"price":69.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/9721\/files\/PendulumMetabolicDaily90ct..webp?v=1787936116","url":"https:\/\/hormonesynergy.com\/products\/https-hormonesynergy-com-products-pendulum-metabolic-daily-probiotic","provider":"HormoneSynergy","version":"1.0","type":"link"}