Why does S-Acetyl Glutathione work better than Reduced L-Gluthione?
S-acetyl glutathione (SAG) is often considered better than reduced glutathione (GSH) in terms of bioavailability and stability. Here are the key reasons why:
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Better Absorption: S-acetyl glutathione has an acetyl group attached to it, which makes it more resistant to breakdown in the digestive tract. This helps it be absorbed more effectively into the bloodstream when taken orally. Reduced glutathione, on the other hand, is often broken down by enzymes before it can be fully absorbed, making it less bioavailable in oral forms.
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Cellular Uptake: S-acetyl glutathione is more easily taken up by cells because the acetyl group protects the glutathione molecule from degradation in the bloodstream. Once inside the cell, the acetyl group is removed, and glutathione is released in its active, reduced form. Reduced glutathione does not have this protective mechanism and is more likely to be degraded before reaching the cells.
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Stability: S-acetyl glutathione is more stable during storage and in the digestive process. It is less susceptible to oxidation, which allows it to retain its potency longer compared to reduced glutathione, which can degrade over time or during digestion.
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Efficacy at Lower Doses: Because S-acetyl glutathione is more bioavailable, smaller doses may be needed to achieve the same effects as higher doses of reduced glutathione. This makes S-acetyl glutathione more efficient in supplement form.
In summary, S-acetyl glutathione is preferred because it offers better absorption, stability, and cellular uptake, making it more effective than reduced glutathione in many cases.