HormoneSynergy® Longevity Medicine is a physician-led preventive health clinic serving Portland and Lake Oswego, Oregon. We use the term longevity medicine to describe a healthspan-focused clinical approach: early disease-risk detection, hormone replacement therapy, metabolic health, preventive cardiology, and advanced diagnostics including DEXA bone density and body composition scans, carotid artery ultrasound, SECA body composition testing, CNS Vital Signs, and AI-assisted coronary CT angiography with Cleerly®.
Led by Dr. Kathryn Retzler, a nationally recognized physician with more than 25 years of clinical experience, HormoneSynergy® emphasizes evidence-informed prevention, metabolic health, cardiovascular risk reduction, hormone balance, and measurable outcomes for patients in Portland, Lake Oswego, and across the United States.
Transparency note: Longevity medicine is an emerging clinical focus, not an ABMS-recognized board specialty. We use the term to describe our preventive, systems-based approach to healthspan, metabolic risk, hormone health, cardiovascular prevention, cognition, strength, and aging-related risk assessment.
Preventive Medicine With a Healthspan Focus
At HormoneSynergy®, we focus on identifying risk early, measuring meaningful changes in physiology and building a physician-guided plan for long-term health. The Optimal Aging Assessment evaluates cardiovascular risk, metabolism, hormones, bone health, body composition and cognition in one integrated assessment.
Comprehensive longevity medicine does not require every available scan, genetic panel or performance test to be included for every patient. Whole-body MRI, genomic testing, VO₂ max and other specialized studies can be added when a patient’s history, risk factors or initial findings indicate that they are likely to provide useful information.
This clinically selective approach keeps comprehensive physician-led longevity medicine more accessible, while reserving additional testing for patients whose history, risk factors or initial findings indicate that it is likely to influence care.
Compare Function Health®, Fountain Life™ and physician-guided longevity care
Preventive Cardiology & Early Heart Disease Detection
HormoneSynergy® is a physician-led longevity medicine clinic in Portland, Oregon specializing in preventive cardiology, metabolic health, hormone optimization, and advanced diagnostic testing. Our approach focuses on early detection of disease risk and personalized, evidence-based prevention strategies.
Cardiovascular disease often develops silently for years before symptoms appear. With more than 25 years of clinical experience in preventive cardiology, Dr. Kathryn Retzler uses advanced imaging, vascular testing, and targeted diagnostics—including Cleerly®-enabled Coronary CT Angiography (CCTA)—to directly visualize coronary plaque and more accurately assess cardiovascular risk.
Rather than relying on indirect markers or late-stage detection, the focus is early identification, precise risk assessment, and proactive care—supporting long-term cardiovascular health and longevity.
Metabolic Health & Medical Weight Loss
Metabolic dysfunction is one of the most important drivers of long-term disease risk. We focus on insulin resistance, body composition, and sustainable weight loss through structured medical care.
- GLP-1–based weight loss programs (semaglutide, tirzepatide)
- Continuous glucose monitoring
- Insulin resistance and metabolic optimization
Hormone Therapy for Men & Women
Hormones influence metabolism, cognition, muscle mass, bone density, and overall quality of life. Our approach focuses on individualized optimization based on symptoms, labs, and long-term goals.
- Testosterone therapy for men and women
- Bioidentical hormone replacement therapy (BHRT)
- Perimenopause, menopause, and andropause care
Advanced Diagnostics & Body Composition and Neurocognitive testing
Advanced diagnostics help move preventive care beyond guesswork. HormoneSynergy® uses tools such as DEXA bone density and visceral fat analysis, SECA body composition testing, CNS Vital Signs neurocognitive testing, carotid artery ultrasound, and Cleerly®-enabled coronary CT angiography when clinically appropriate.
These assessments help evaluate bone health, visceral fat, lean mass, cognitive performance, vascular risk, and early cardiometabolic changes so care can be guided by measurable data rather than symptoms alone.
Neurocognitive Testing
CNS Vital Signs (CNSVS) is a computerized, HIPAA-compliant neurocognitive assessment platform designed for rapid, objective, and longitudinal evaluation of brain function in patients ages 8–90. It functions as a “fitness test” for the brain, measuring key domains such as memory, processing speed, attention, and executive function. These insights help clinicians identify patterns, track changes over time, and support the evaluation of conditions including ADHD, concussion, and mild cognitive impairment within a broader longevity medicine framework.
Explore the HormoneSynergy® Longevity Medicine Resource Library
The HormoneSynergy® Longevity Medicine Resource Library is a free patient-education hub reflecting Dr. Kathryn Retzler’s clinical perspective and Daniel Soule’s editorial voice as Clinic Director and owner.
For patients who want to understand the science behind our approach, the Resource Library organizes our educational articles by topic, including metabolic health, preventive cardiology, hormone transitions, brain health, sleep, gut health, inflammation, food quality, environmental exposure, advanced diagnostics, and evidence-based aging.
It is designed to help patients think more clearly about healthspan, risk reduction, diagnostics, and whole-person preventive care without relying on hype, trends, or influencer medicine.
Supplements in Longevity Medicine
HormoneSynergy® uses supplements as clinical tools, not as a substitute for medicine. Dr. Kathryn Retzler may recommend targeted nutritional support for metabolic health, cardiovascular health, brain health, hormone health, gut health and healthy aging based on the individual patient’s needs.
Recommendations may include RetzlerRx® physician-formulated supplements and selected professional products from Designs for Health®, Metagenics®, Xymogen®, Researched Nutritionals® and Microbiome Labs® when clinically appropriate.
Medicine, not marketing. More supplements do not necessarily mean better medicine.
Advanced Diagnostics & Concierge Longevity Medicine Services
At HormoneSynergy®, we combine physician-guided longevity medicine with advanced diagnostic testing to detect disease risk early and guide personalized prevention strategies.
Our approach integrates cardiovascular screening, body composition and metabolic testing, hormone optimization, and cognitive performance evaluation—providing a comprehensive understanding of your health before symptoms develop.
I’ve been Dr. Retzler’s patient for nearly 24 years, and I consider myself very fortunate to have found her. With her guidance and bioidentical hormone treatment, I’ve eased through menopause enjoying vibrant health and well-being. I feel wonderful!*
Judith Bernards
At HormoneSynergy®, we focus on identifying risk early, measuring meaningful changes in physiology and building a physician-guided plan for long-term health. The Optimal Aging Assessment evaluates cardiovascular risk, metabolism, hormones, bone health, body composition and cognition in one integrated assessment.
Comprehensive longevity medicine does not require every available scan, genetic panel or performance test to be included for every patient. Whole-body MRI, genomic testing, VO₂ max and other specialized studies can be added when a patient’s history, risk factors or initial findings indicate that they are likely to provide useful information.
This selective approach allows HormoneSynergy® to provide comprehensive physician-led longevity medicine without requiring every patient to pay for testing that may not change care.
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