Inflammaging: The Silent Driver of Aging—and Why Suppressing Inflammation Isn’t Enough
At HormoneSynergy® Clinic, longevity medicine means looking deeper than symptoms—and even deeper than diagnoses. One of the most important, yet misunderstood, processes driving aging and chronic disease today is inflammaging.
Inflammaging refers to chronic, low-grade, unresolved inflammation that persists silently in the body over time. Unlike acute inflammation—which is essential for healing—this smoldering inflammatory state accelerates biological aging and contributes to nearly every major age-related condition.
Inflammaging is Linked to:
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Cardiovascular disease and endothelial dysfunction
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Insulin resistance and metabolic dysfunction
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Joint degeneration, stiffness, and chronic pain
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Cognitive decline and neuroinflammation
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Accelerated biological aging and reduced healthspan
This is not fringe science. Inflammaging is now recognized as a core mechanism of aging itself.
The Problem With “Blocking” Inflammation
Most people are taught that inflammation is the enemy.
So they try to:
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Block it with NSAIDs
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Suppress it with steroids
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Inhibit it with supplements that shut down inflammatory pathways
While these approaches may temporarily reduce symptoms, they miss the fundamental issue.
The real problem isn’t just inflammation—it’s the body’s failure to properly resolve it.
Inflammation is not meant to linger. In a healthy system, inflammation:
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Turns on in response to stress or injury
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Does its job
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Actively resolves and turns off
With aging, poor metabolic health, chronic stress, ultra-processed diets, and environmental burden, that final step—resolution—often breaks down.
Resolution Is an Active Biological Process
For decades, medicine believed inflammation simply faded away on its own. We now know that resolution is biochemically active and highly regulated.
The body relies on specialized signaling molecules to:
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Clear inflammatory debris
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Calm immune overactivation
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Restore tissue balance
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Protect healthy cells from collateral damage
When these resolution pathways are impaired, inflammation becomes chronic—even if it’s “low-grade” and hard to detect on standard labs.
This is the essence of inflammaging.
Why Inflammaging Accelerates Aging
Unresolved inflammation quietly damages tissues over time:
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Blood vessels lose flexibility and resilience
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Insulin signaling becomes impaired
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Joints break down faster than they can repair
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The brain becomes more vulnerable to cognitive decline
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Cellular aging accelerates at the mitochondrial and DNA level
This is why inflammaging is now considered a central pillar of longevity medicine, not just an inflammatory issue.
A Longevity-Focused Shift: From Suppression to Resolution
At HormoneSynergy® Clinic, we take a Medicine 3.0 approach to inflammation—one that prioritizes long-term healthspan, not short-term symptom masking.
That means:
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Identifying drivers of chronic inflammation
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Supporting metabolic and vascular health
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Optimizing gut-immune signaling
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And critically—supporting the body’s natural inflammation-resolution pathways
This is where resolution-focused nutrition and targeted supplementation become powerful tools when used appropriately and clinically.
Resolution Support & RetzlerRx® Philosophy
RetzlerRx® formulations are curated through a longevity lens—prioritizing:
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Evidence-informed ingredients
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Cellular and vascular health
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Immune balance rather than immune suppression
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Support for the body’s innate ability to restore equilibrium
Rather than “turning inflammation off,” the goal is to help the body complete the inflammatory cycle properly—a subtle but profound distinction with implications for cardiovascular longevity, metabolic resilience, joint integrity, and brain health.
The Takeaway
Inflammaging isn’t loud. It doesn’t always cause immediate pain. But over years, it quietly erodes health, resilience, and longevity.
Suppressing inflammation alone is an incomplete strategy.
Resolution is the missing piece.
Supporting the body’s ability to resolve inflammation—rather than simply blocking it—represents one of the most important paradigm shifts in modern longevity medicine.
Explore Inflammation-Resolution Support
Support healthy aging at the root—not just the symptoms.
Explore Dr. Retzler’s clinically curated inflammation-resolution supplements from RetzlerRx®, designed to support cardiovascular health, joint comfort, metabolic balance, and long-term resilience.