Cholest-Protect - Cholesterol Support*

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Citrus Bergamot Bergamonte®, Berberine and Curcumin C3 Complex

Cholest Protect contains citrus bergamot, berberine, and Curcumin. These 3 ingredients effectively and safely support normal lipid metabolism and cholesterol levels*. Supplementation of citrus bergamot (Citrus bergamia) inhibits HMG-CoA reductase, reducing LDL in addition to lowering triglycerides*. Bergamot decreases blood sugar, and small dense LDL, and improves HDL and fatty liver*. Bergamonte® is produced using patented extraction technology through collaborative works of various Universities and research institutions in Italy. These flavanoids are clinically proven to help maintain healthy cholesterol level†, healthy blood glucose levels, increase HDL-cholesterol, and promoting healthy weight management.*

Berberine, the bright yellow alkaloid found in Oregon grape root and goldenseal, has extensive beneficial effects in reducing cardiovascular risk*. Berberine effectively improves glucose metabolism and insulin sensitivity, and has been shown to be as effective as some medications in lowering blood sugar*. It has pleotropic effects in blood vessel and heart health by reducing inflammation, increasing nitric oxide production, and enhancing endothelial function*. Berberine also improves mobilization and function of endothelial progenitor cells (the cells that repair damaged blood vessels)*. Berberine reduces triglycerides and LDL through a unique mechanism distinct from statins. One small study showed that berberine can improve symptoms and extend life span in congestive heart failure patients*.

*HormoneSynergy supplements are not meant to be taken as an alternative to prescription medications recommended by your physician. If you are seeking to replace any pharmaceutical medication with any of our products we recommend that you do so only after consulting your healthcare provider.

*The information provided on this page is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Please seek advice from a medical professional to help evaluate your symptoms and condition for proper diagnosis.

(Clinical References Supporting Individual ingredients):

*Mollace V, et al. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia. 2011;82:309–316.

*Gliozzi M, et al. The effect of bergamot-derived polyphenolic fraction on LDL small dense particles and non alcoholic fatty liver disease in patients with metabolic syndrome. Advances in Biological Chemistry. 2014;4:129-137. 292Rumberger JA, et al. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a tripleblinded placebo and diet-controlled investigation. Nutr Res. 2011;31(8):608-15. 

*Gaddi A, et al. Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia. Atherosclerosis. 1984;50(1):73-83

*Zhang Q, et al. Berberine moderates glucose and lipid metabolism through mulitpathway mechanisms. Evid Based Complement Alternat Med. 2011;924851.

*Yin J, et al. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 208;57(5): 712-7. 296Affuso F, et al. Cardiovascular and metabolic effects of berberine. World J of Cardiol. 2010;2(4):71-77.

*Wu M, et al. Advance of studies on anti-atherosclerosis mechanism of berberine. Chin J Integr Med. 2010;16(2):188-92.

*Brusq JM, et al. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res. 2006;47(6):1281-8.

*Kong W, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004;10(12):1344-51.

*Xu MG, et al. Berberine-induced upregulation of circulating endothelial progenitor cells is related to nitric oxide production in healthy subjects. Cardiology 2009;112:279-286.

*Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity. Xu, M. et al Journal of Human Hypertension (2008) 22, 389-93