Vitamin B12 and folate work together in essential biochemical pathways throughout the body. RetzlerRx® Methyl B-12 Synergy Plus provides high-potency methylcobalamin and active 5-MTHF folate in a convenient cherry-flavored tablet that dissolves quickly in the mouth.
This targeted combination supports methylation, cellular energy metabolism, neurological health, DNA synthesis, red blood cell formation, and healthy homocysteine metabolism.* It is particularly useful for adults seeking more focused B12 and folate support than a general multivitamin or standard B-complex provides.*
- Adults seeking high-potency methylated B12 and active folate support*
- Individuals focused on methylation and homocysteine metabolism*
- People seeking neurological and cognitive support*
- Adults with increased B12 needs related to diet, age, digestion, or medication use*
- Individuals who prefer a quick-dissolve tablet instead of a capsule*
What Each Tablet Provides
- Vitamin B12: 5,000 mcg as methylcobalamin
- Folate: 1,700 mcg DFE as Quatrefolic® 5-MTHF
- Format: Cherry-flavored quick-dissolve tablet
- Supply: 60 tablets
This is a high-potency formula designed for targeted B12 and folate supplementation.*
Why Combine Vitamin B12 and Active Folate?
Vitamin B12 and folate function as nutritional partners in one-carbon metabolism. Together, they participate in methylation reactions, DNA synthesis, red blood cell production, neurological function, and the conversion of homocysteine to methionine.*
Providing both nutrients in bioactive forms creates a coordinated formula that supports these interconnected pathways more comprehensively than using either nutrient alone.*
Methylcobalamin Vitamin B12
Methylcobalamin is a coenzyme form of vitamin B12 used directly in the methionine synthase pathway. In this pathway, vitamin B12 works with folate to support methylation and healthy homocysteine metabolism.*
Vitamin B12 also supports:
- Normal energy metabolism*
- Healthy red blood cell formation*
- Neurological and nerve function*
- DNA synthesis and cellular renewal*
- Healthy cognitive function*
Each quick-dissolve tablet provides 5,000 mcg of methylcobalamin for high-potency B12 support.* Large oral amounts are commonly used because only a portion of supplemental B12 is absorbed through the digestive system.
Quatrefolic® 5-MTHF Active Folate
Quatrefolic® is a branded form of 5-methyltetrahydrofolate, commonly called 5-MTHF or methylfolate. It is a biologically active form of folate used in methylation and one-carbon metabolism.*
Providing folate as 5-MTHF eliminates the need to convert synthetic folic acid into its active methylated form before it can participate in folate-dependent pathways.*
Active folate supports:
- Methylation and cellular metabolism*
- Healthy homocysteine processing*
- DNA synthesis and cell division*
- Normal red blood cell production*
- Neurological and cognitive wellness*
The label amount is expressed as 1,700 mcg DFE, or dietary folate equivalents. DFE is the standardized labeling unit used to account for differences in the bioavailability of supplemental and naturally occurring food folate.
Methylation and Homocysteine Support
Methylation is involved in gene expression, neurotransmitter metabolism, cellular repair, detoxification pathways, and many other biochemical processes.*
Vitamin B12 and folate work together in the conversion of homocysteine to methionine. Maintaining adequate levels of both nutrients supports healthy methylation and homocysteine metabolism.*
Methyl B-12 Synergy Plus may be considered when dietary intake, laboratory findings, medication use, digestive factors, or an individualized health plan indicate a need for additional B12 and folate support.*
Energy and Cellular Metabolism
Vitamin B12 is required for normal cellular energy metabolism and healthy red blood cell formation.* Red blood cells help deliver oxygen throughout the body, while B12-dependent pathways help cells process nutrients efficiently.*
For individuals with inadequate B12 status, restoring nutritional sufficiency may support energy, stamina, and overall vitality.*
Brain and Neurological Support
Vitamin B12 and folate are important for normal neurologic function, neurotransmitter metabolism, and the maintenance of healthy nerve cells.*
Adequate B12 and folate status supports cognitive function, mental clarity, mood-related biochemical pathways, and long-term brain health.* This makes the formula relevant within a broader longevity strategy focused on vascular health, metabolic function, sleep, exercise, and cognitive resilience.*
Who May Benefit From Targeted B12 and Folate Support?
Methyl B-12 Synergy Plus may be considered by adults with factors such as:
- Limited intake of animal-derived foods*
- A vegan or predominantly plant-based diet*
- Older age or reduced stomach-acid production*
- Long-term metformin or acid-suppressing medication use*
- A history of bariatric surgery or gastrointestinal conditions affecting absorption*
- Laboratory findings involving B12, methylmalonic acid, folate, or homocysteine*
- A clinician-identified need for high-potency methylation support*
Quick-Dissolve Convenience
The cherry-flavored tablet dissolves directly in the mouth, providing convenient daily supplementation without the need to swallow a capsule.*
This format may be especially useful for individuals who have difficulty swallowing pills or prefer a quick-dissolve delivery method.*
Suggested Use
Dissolve one tablet in the mouth daily, or use as directed by your healthcare professional.
Because this is a high-potency formula, individualized dosing may be appropriate when it is being used in response to laboratory findings, medication use, dietary patterns, or digestive absorption concerns.
The HormoneSynergy® Perspective
Methyl B-12 Synergy Plus provides two closely connected nutrients in active forms and clinically relevant amounts. It is a strong choice for adults seeking focused support for methylation, homocysteine metabolism, neurological health, red blood cell production, and cellular energy pathways.*
At HormoneSynergy® Longevity Medicine, B12 and folate may be considered alongside a complete blood count, serum B12, methylmalonic acid, folate, homocysteine, kidney function, thyroid function, diet, digestive health, and relevant medication use. This helps connect supplementation to the individual’s broader metabolic and neurological picture.
Safety and Use Considerations
Consult your healthcare professional before use if you are pregnant or planning pregnancy, are receiving treatment for a medical condition, or take medications that affect folate or vitamin B12 metabolism. This high-potency formula should not automatically replace a prenatal vitamin or clinician-directed folic acid regimen.
Related HormoneSynergy® Resources
Frequently Asked Questions
What does Methyl B-12 Synergy Plus support?
It supports methylation, homocysteine metabolism, neurological function, red blood cell formation, DNA synthesis, and cellular energy metabolism.*
How much vitamin B12 is in each tablet?
Each tablet provides 5,000 mcg of vitamin B12 as methylcobalamin.
How much active folate is in each tablet?
Each tablet provides 1,700 mcg DFE of folate as Quatrefolic® 5-MTHF.
Why combine methylcobalamin with 5-MTHF?
Vitamin B12 and folate work together in methylation, homocysteine metabolism, DNA synthesis, red blood cell production, and neurological pathways.*
What is Quatrefolic®?
Quatrefolic® is a branded form of 5-MTHF, the active methylated form of folate used in one-carbon metabolism.*
Who may benefit from high-potency B12 support?
People with limited animal-food intake, digestive absorption concerns, medication-related risk, or laboratory findings suggesting increased B12 needs may consider targeted supplementation with professional guidance.*
How should I take Methyl B-12 Synergy Plus?
Dissolve one tablet in the mouth daily, or use as directed by your healthcare professional.
*Important Notice: Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Information provided is educational and should not replace personalized medical advice.
For best results, supplements should be used as part of a comprehensive health strategy including nutrition, exercise, restorative sleep, stress management, and appropriate medical evaluation when necessary.