Why Specialized Pro-Resolving Mediators (SPMs) Are One of Dr. Retzler’s Top 5 Longevity Supplements
In longevity medicine, the goal isn’t just to reduce symptoms—it’s to restore balance, resilience, and long-term function at the cellular level. After more than 25 years in clinical practice, Dr. Kathryn Retzler has identified a short list of supplements that consistently deliver meaningful, measurable benefits for healthy aging.
Specialized Pro-Resolving Mediators (SPMs) are firmly on that list.
Here’s why SPMs are considered one of Dr. Retzler’s Top 5 Longevity Supplements.
The Missing Link in Inflammation Management
Chronic, low-grade inflammation—often called “inflammaging”—is a core driver of aging and age-related disease. It contributes to:
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Cardiovascular disease
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Insulin resistance and metabolic dysfunction
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Joint degeneration and chronic pain
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Cognitive decline
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Accelerated biological aging
Most people focus on blocking inflammation with NSAIDs, steroids, or even supplements that suppress inflammatory pathways. But that approach is incomplete.
The real issue isn’t just inflammation—it’s failure to properly resolve it.
This is where SPMs are fundamentally different.
What Are SPMs (Specialized Pro-Resolving Mediators)?
SPMs are bioactive lipid signaling molecules derived from omega-3 fatty acids (EPA and DHA). Unlike standard fish oil, SPMs are not anti-inflammatory suppressors. Instead, they:
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Actively turn off inflammation when it’s no longer needed
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Signal the immune system to clear damaged cells and debris
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Support tissue repair and regeneration
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Restore immune balance without impairing immune defense
In simple terms:
SPMs help your body finish the job inflammation started.
Why Dr. Retzler Prioritizes SPMs for Longevity
1. They Address the Root Cause of Chronic Inflammation
Many patients eat well, exercise, and even take omega-3s—yet inflammation markers remain elevated. Why? Because conversion of omega-3s into SPMs declines with age, stress, metabolic disease, and chronic illness.
Supplementing with pre-formed SPMs bypasses this bottleneck and restores the body’s natural resolution pathways.
2. Cardiovascular Protection Without Immune Suppression
Unresolved vascular inflammation is a key contributor to:
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Atherosclerosis
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Endothelial dysfunction
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Plaque instability
SPMs support vascular healing and plaque stabilization without blunting the immune system—making them ideal for long-term cardiovascular longevity strategies.
3. Joint, Muscle, and Recovery Support
For active adults and aging athletes, SPMs are invaluable. They help:
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Resolve post-exercise inflammation
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Support joint comfort and mobility
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Improve recovery without masking pain signals
This is one reason SPMs are frequently included in Dr. Retzler’s joint, muscle, and performance-focused longevity protocols.
4. Brain Health and Neuro-Longevity
Neuroinflammation plays a role in:
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Cognitive decline
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Mood disorders
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Neurodegenerative conditions
SPMs cross the blood-brain barrier and support healthy neuro-immune signaling, making them a powerful tool for brain aging, focus, and long-term cognitive resilience.
5. A Smarter Alternative to Chronic Anti-Inflammatory Use
Long-term use of NSAIDs or immune-suppressing agents can impair healing and increase risk. SPMs offer a physiologic, restorative approach—supporting the body’s natural intelligence rather than overriding it.
Why Fish Oil Alone Isn’t Enough
Many people assume they’re covered because they take omega-3 supplements. But omega-3s are merely raw materials. The body still has to convert them into SPMs—and that process is often impaired.
That’s why Dr. Retzler often recommends:
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High-quality omega-3s plus
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Targeted SPM supplementation
Together, they support both prevention and resolution of inflammation.
Longevity Medicine Perspective: Resolution Is the Goal
At HormoneSynergy® Clinic, longevity medicine isn’t about chasing lab numbers or suppressing symptoms. It’s about restoring the body’s ability to adapt, heal, and thrive over decades.
SPMs align perfectly with this philosophy.
They don’t fight the body—they guide it back to balance.
That’s why they remain one of Dr. Retzler’s Top 5 Longevity Supplements and a cornerstone of many personalized protocols.
Support Inflammation Resolution at the Cellular Level
Experience RetzlerRx® Specialized Pro-Resolving Mediators (SPMs)
At HormoneSynergy® Clinic, we don’t rely on generic anti-inflammatory supplements. RetzlerRx® SPMs are selected for patients and longevity-focused individuals who want to address chronic inflammation at its root—by restoring the body’s natural resolution pathways.
Unlike standard fish oil, RetzlerRx® SPMs deliver pre-formed Specialized Pro-Resolving Mediators to support:
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Cardiovascular and vascular longevity
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Joint comfort, mobility, and recovery
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Healthy immune balance
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Brain health and neuro-inflammation support
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Long-term resilience as we age
This is the same category of supplement Dr. Kathryn Retzler includes in her personal Top 5 Longevity Supplements, and one she frequently recommends as part of individualized longevity medicine protocols.
These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare professional before starting any new supplement.