AI Overview
RetzlerRx® Active Folate B12 Synergy combines two biologically active B vitamins in one quick-dissolve cherry tablet: 1,000 mcg of L-5-MTHF, providing 1,700 mcg dietary folate equivalents (DFE), and 2,500 mcg of methylcobalamin vitamin B12. Folate and B12 work together in one-carbon metabolism, DNA synthesis, red blood cell formation, neurologic function, and pathways involved in homocysteine metabolism.* This is a high-potency formula intended for targeted supplementation rather than casual use simply because someone has heard they may carry an MTHFR variant.
Best For
- Targeted active-folate and methylcobalamin supplementation*
- Methylation and homocysteine metabolism support*
- Normal red blood cell and DNA synthesis support*
- Neurologic and cognitive nutrient support*
- People who prefer a quick-dissolve tablet instead of a capsule
Active Folate and Methylated B12 in One Quick-Dissolve Tablet*
RetzlerRx® Active Folate B12 Synergy pairs L-5-methyltetrahydrofolate, commonly called 5-MTHF or methylfolate, with methylcobalamin, a biologically active form of vitamin B12.
These nutrients are closely connected. Folate supplies one-carbon units used in methylation and DNA synthesis, while vitamin B12 helps recycle folate and supports the conversion of homocysteine back to methionine.* Both are also necessary for normal red blood cell production and neurologic function.*
The combination makes sense when there is a clear reason to support folate and B12 status together.* It should not, however, be treated as a universal energy supplement or as proof that everyone with an MTHFR variant needs a high-dose methylated product.
What Is in One Quick-Dissolve Tablet?
- Folate: 1,700 mcg DFE, supplied as 1,000 mcg of L-5-MTHF from Quatrefolic®
- Vitamin B12: 2,500 mcg, supplied as MecobalActive™ methylcobalamin
- Quick-dissolve cherry tablet
- 30 tablets per container
Label clarification: The folate amount is properly expressed as 1,700 mcg DFE. The tablet supplies 1,000 mcg of actual L-5-MTHF. Dietary folate equivalents account for differences in the bioavailability of supplemental folate and naturally occurring food folate.
Why Use 5-MTHF?
5-MTHF is the principal circulating form of folate and can participate directly in folate-dependent metabolic pathways.* Unlike synthetic folic acid, it does not require conversion through the MTHFR enzyme before entering the methylation cycle.
This may be useful when a clinician wants to provide active folate directly.* It does not mean that synthetic folic acid is inherently harmful or that 5-MTHF produces superior outcomes for every person.
Common MTHFR gene variants can influence folate metabolism, but a genetic result should be interpreted alongside diet, symptoms, medication use, folate status, vitamin B12 status, complete blood count findings, and homocysteine. A gene variant is not a diagnosis.
Why Pair Folate With Vitamin B12?
Folate and B12 meet at several important metabolic intersections:
- Homocysteine metabolism: Folate and B12 participate in the remethylation of homocysteine to methionine.*
- DNA synthesis: Both nutrients are necessary for normal cell division and DNA production.*
- Red blood cell formation: Inadequate folate or B12 can disrupt normal red blood cell development.*
- Neurologic function: Vitamin B12 is necessary for normal nerve integrity and neurological function.*
- Methylation: Folate and B12 help sustain the production and recycling of methyl groups used throughout cellular metabolism.*
Pairing folate with B12 also matters because large amounts of folate can improve the blood abnormalities caused by B12 deficiency while neurological injury continues. This formula contains substantial B12, but persistent neurologic symptoms, macrocytosis, anemia, or suspected malabsorption still require proper evaluation.
Will It Increase Energy?
Folate and vitamin B12 participate in metabolic processes required for normal energy production and oxygen delivery.* Correcting an actual deficiency may improve fatigue related to that deficiency.
Taking more B12 or folate does not automatically create additional energy when nutrient status is already sufficient. Fatigue may instead reflect sleep disruption, thyroid disease, anemia, iron deficiency, metabolic dysfunction, medication effects, depression, cardiovascular disease, hormonal changes, or another medical issue.
Who May Benefit?
This formula may be considered for adults who:
- Have a documented or suspected need for supplemental folate or B12*
- Are following a clinician-directed homocysteine strategy*
- Use medications associated with reduced B12 status, including metformin or long-term acid-suppressing therapy*
- Follow a vegan or vegetarian diet with limited dietary B12*
- Have age-related, gastrointestinal, or dietary factors that may affect B12 status*
- Prefer a quick-dissolve tablet rather than swallowing a capsule
Testing Before Guessing
More is not always better. Depending on the clinical question, evaluation may include:
- Complete blood count and red blood cell indices
- Serum vitamin B12
- Serum or red blood cell folate
- Methylmalonic acid
- Homocysteine
- Medication, dietary, and gastrointestinal review
Serum B12 alone does not always provide the full picture. Methylmalonic acid can be helpful when functional B12 deficiency remains a concern, while homocysteine may be influenced by folate, B12, vitamin B6, kidney function, thyroid status, genetics, medications, and other factors.
Important Considerations
- This is a high-potency folate and B12 formula.
- Methylated B vitamins may feel stimulating to some people. If that occurs, discuss the dose and timing with your healthcare professional.
- Do not use a folate supplement as a substitute for evaluating anemia, neuropathy, cognitive changes, persistent fatigue, or an elevated homocysteine level.
- People receiving treatment for cancer, taking medications that affect folate metabolism, or managing a seizure disorder should discuss high-dose folate supplementation with their treating clinician.
- Pregnant individuals or those planning pregnancy should follow personalized prenatal guidance rather than assuming that every high-dose methylfolate product is an appropriate prenatal supplement.
Suggested Use
Take 1 quick-dissolve cherry tablet daily or as directed by your healthcare professional. Allow the tablet to dissolve in the mouth before swallowing.
HormoneSynergy® Resources
Frequently Asked Questions
What does Active Folate B12 Synergy support?
The formula provides active folate and methylcobalamin B12 to support methylation, homocysteine metabolism, DNA synthesis, red blood cell production, neurologic function, and normal energy metabolism.*
How much 5-MTHF does each tablet contain?
Each tablet supplies 1,000 mcg of L-5-MTHF from Quatrefolic®, expressed on the Supplement Facts label as 1,700 mcg dietary folate equivalents.
How much vitamin B12 does it contain?
Each tablet supplies 2,500 mcg of vitamin B12 as MecobalActive™ methylcobalamin.
Is 1,700 mcg the amount of actual 5-MTHF?
No. The tablet provides 1,000 mcg of L-5-MTHF, which is expressed as 1,700 mcg DFE under current supplement-labeling conventions.
What is 5-MTHF?
5-MTHF is 5-methyltetrahydrofolate, a biologically active form of folate used in one-carbon metabolism and methylation pathways.*
Why combine folate with vitamin B12?
Folate and B12 work together in DNA synthesis, red blood cell development, methylation, and the conversion of homocysteine to methionine.*
Do I need this product if I have an MTHFR variant?
Not necessarily. Common MTHFR variants do not establish a folate deficiency or automatically create a need for high-dose methylfolate. Supplement decisions should consider diet, symptoms, laboratory findings, medications, pregnancy status, and the broader clinical picture.
Can this product treat an elevated homocysteine level?
No. Folate and B12 participate in homocysteine metabolism,* but an elevated result may have several causes and should be evaluated rather than treated blindly with a supplement.
Is this an energy booster?
Folate and B12 support normal energy metabolism,* but taking high doses does not necessarily increase energy when nutrient status is already sufficient.
How should I take it?
Take 1 quick-dissolve tablet daily or as directed by your healthcare professional. Allow it to dissolve in the mouth before swallowing.
*Important Notice: Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Information provided is educational and should not replace personalized medical advice.
For best results, supplements should be used as part of a comprehensive health strategy including nutrition, exercise, restorative sleep, stress management, and appropriate medical evaluation when necessary.