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5-MTHF Extra Strength active folate supplement by RetzlerRx supporting methylation and cardiovascular healthHormoneSynergy
5-MTHF Extra Strength | Advanced Folate Supplement for Energy & Heart Health | Premium RetzlerRx Supplement 5-MTHF / Methylation Dr. Retzler’s Line of Premier Supplements HormoneSynergy
5-MTHF Extra Strength | Advanced Folate Supplement for Energy & Heart Health | Premium RetzlerRx Supplement 5-MTHF / Methylation Dr. Retzler’s Line of Premier Supplements HormoneSynergy

5-MTHF Extra Strength | Active Folate for Methylation & Heart Health

Regular price
$ 79.99
Sale price
$ 75.99
Quantity must be 1 or more

5-MTHF Extra Strength | Active Folate for Methylation & Heart Health

Support optimal methylation, cardiovascular wellness, and cellular energy with 5-MTHF Extra Strength by RetzlerRx®, a physician-formulated active folate supplement designed for individuals seeking a bioavailable alternative to traditional folic acid.

Best for: Individuals seeking active folate support for methylation, healthy homocysteine metabolism, cardiovascular wellness, and cellular energy.

5-MTHF (5-methyltetrahydrofolate) is the biologically active form of folate used directly by the body in key metabolic pathways. Unlike synthetic folic acid, 5-MTHF does not require multiple enzymatic conversions before it can support methylation, homocysteine metabolism, and normal cellular function.

Key Benefits

  • Active Folate Support – Provides 5-MTHF, the bioavailable form of folate used directly by the body.
  • Methylation Support – Supports key biochemical pathways involved in methylation and cellular metabolism.
  • Heart Health Support – Helps support healthy homocysteine metabolism already within the normal range.
  • Energy Metabolism – Folate plays an essential role in normal cellular energy pathways.
  • Neurological Support – Supports normal brain and nervous system function.

Who May Benefit

  • Individuals seeking methylation support
  • Those interested in supporting healthy homocysteine metabolism
  • People wanting a high-quality alternative to folic acid
  • Individuals focused on cardiovascular and metabolic wellness

Why RetzlerRx®

RetzlerRx® supplements are developed using practitioner-grade standards and clinically relevant formulations. These products are aligned with the philosophy of HormoneSynergy® Longevity Medicine, where nutrition, diagnostics, and evidence-based preventive care are used to support long-term health.

  • Physician-formulated
  • Non-GMO ingredients
  • Gluten-free
  • No unnecessary fillers

Frequently Asked Questions

What is 5-MTHF?

5-MTHF (5-methyltetrahydrofolate) is the biologically active form of folate used directly in the body’s methylation pathways.

Why choose 5-MTHF instead of folic acid?

Folic acid must be converted through several enzymatic steps before becoming biologically active, whereas 5-MTHF is already in its usable form.

Who may benefit from active folate supplements?

Individuals interested in supporting methylation pathways, cardiovascular health, or homocysteine metabolism often choose active folate supplements.

Is this supplement practitioner grade?

Yes. RetzlerRx® supplements are physician-formulated and produced using practitioner-grade quality standards.


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

HormoneSynergy® Longevity Medicine
Portland • Lake Oswego • Oregon
Evidence-Based Preventive Longevity Medicine