RetzlerRx® Pure Omega 1300 EC with MaxSimil® | 120 Softgels

Concentrated EPA and DHA in One Enteric-Coated Softgel*

RetzlerRx® Pure Omega 1300 EC uses MaxSimil® technology to deliver EPA and DHA primarily in monoglyceride form. The formula is intended to reduce the digestive work required before omega-3 fatty acids can be absorbed.*

Each softgel contains 1,300 mg of MaxSimil® fish-oil concentrate and provides:

• EPA: 600 mg
• DHA: 260 mg
• Combined EPA plus DHA: 860 mg

The “1300” in the product name refers to the amount of fish-oil concentrate, not to 1,300 mg of EPA plus DHA. The actual combined EPA and DHA amount is 860 mg per softgel.

That distinction matters whenever fish oils are compared. The most useful numbers on the label are the amounts of EPA and DHA, not simply the total milligrams of fish oil.

What Is MaxSimil®?

Dietary fat is normally broken down by digestive enzymes before it can be absorbed. Ethyl ester fish oils require additional processing in the digestive tract, and their absorption can depend substantially on the fat content of the accompanying meal.

MaxSimil® uses an enzymatic process to convert concentrated fish oil into monoglycerides before it is placed in the softgel. Monoglycerides are intermediates normally created during fat digestion, making the oil more immediately available for intestinal absorption.*

The manufacturer describes MaxSimil® as providing three-times-greater EPA and DHA absorption than an equivalent ethyl ester fish oil.* That claim needs context.

In a published randomized crossover trial involving 22 adults who took approximately 1.2 grams of EPA and DHA with low-fat meals, monoglyceride omega-3s produced greater overall plasma omega-3 exposure than ethyl ester and triglyceride forms. The 24-hour EPA exposure was approximately twice that of the ethyl ester form and similar to the triglyceride form. Digestive side effects did not differ significantly among the three formulations.

The practical takeaway is that monoglyceride delivery has legitimate pharmacokinetic evidence behind it.* It should not be interpreted as proof that one MaxSimil® capsule produces three times the clinical benefit of every other fish oil.

Why Absorption Can Matter

Fish-oil absorption is influenced by the chemical form of the oil, digestive function and the composition of the meal taken with it. Ethyl ester products are generally absorbed better when consumed with dietary fat.

A monoglyceride formula may be particularly appealing to someone who eats low-fat meals, has difficulty taking fish oil consistently or wants more efficient EPA and DHA delivery from a single softgel.*

Better acute absorption does not eliminate the importance of dose, consistency or the actual clinical goal. Someone using omega-3s for general nutritional support may need a different dose than someone being treated for severe hypertriglyceridemia.

EPA and DHA Are Related, but Not Identical

EPA and DHA are long-chain marine omega-3 fatty acids with overlapping but distinct biological roles.

EPA participates in lipid-signaling pathways and serves as a precursor for compounds involved in normal inflammatory regulation and resolution.* It has also been studied extensively in relation to triglyceride metabolism and cardiovascular physiology.*

DHA is an important structural component of neural and retinal cell membranes.* It is especially concentrated in the brain and retina and contributes to normal membrane fluidity and signaling.*

Pure Omega 1300 EC provides more EPA than DHA, with 600 mg EPA and 260 mg DHA per softgel. This creates a concentrated EPA-forward formula while still supplying a meaningful amount of DHA.

Omega-3s and Cardiovascular Health

EPA and DHA can lower triglyceride concentrations when used at clinically meaningful doses.* The magnitude of the effect depends on the dose, starting triglyceride level, formulation, diet, alcohol intake, glucose regulation and the cause of the elevation.

One Pure Omega 1300 EC softgel provides 860 mg of combined EPA and DHA. That is a substantial nutritional dose. It is not the same as the 2-to-4-gram daily doses of prescription omega-3 fatty acids commonly used to treat significant hypertriglyceridemia.

It also should not be assumed that every fish-oil product produces the same cardiovascular outcomes. Some of the strongest cardiovascular-event evidence involves a specific purified prescription EPA product used in selected higher-risk patients receiving statin therapy. Those findings cannot simply be transferred to every over-the-counter EPA/DHA supplement.

At HormoneSynergy®, cardiovascular prevention is not reduced to fish oil. Depending on the person, the larger picture may include apoB, LDL cholesterol, triglycerides, Lp(a), blood pressure, insulin resistance, smoking, body composition, diet, exercise, vascular imaging, coronary imaging and appropriate medication.

Brain, Eye and Cell-Membrane Support

DHA is a structural component of brain and retinal cell membranes, while EPA and DHA participate in cellular signaling and normal inflammatory physiology.* Maintaining adequate omega-3 status may therefore support broader brain, retinal and cell-membrane nutrition.*

That is not proof that taking fish oil prevents dementia, reverses cognitive impairment or treats an eye disease. Cognitive longevity still depends heavily on vascular health, blood pressure, metabolic health, sleep, physical activity, hearing, social engagement and appropriate medical evaluation.

Joint Comfort and Inflammatory Signaling

EPA and DHA provide substrates for lipid mediators involved in the regulation and resolution of normal inflammatory responses.* This is more accurate than describing fish oil as simply “anti-inflammatory.”

Inflammation is necessary for immune defense, tissue repair and recovery. The goal is not to eliminate it. The more useful concept is resolution: the active process through which an appropriate inflammatory response returns toward homeostasis.

Omega-3 supplementation may support joint comfort and normal inflammatory balance in selected adults.* It is not a treatment for inflammatory arthritis, autoimmune disease or an unexplained painful joint.

Enteric Coating and Fishy Aftertaste

The softgel uses an enteric coating designed to delay release until it has moved beyond the stomach. This may help reduce fishy aftertaste or reflux for some users.*

Enteric coating does not guarantee that no one will experience burping, nausea, abdominal discomfort or another digestive side effect. Individual tolerance still varies.

Quality and Sourcing

• IFOS 5-Star certified: Independently evaluated for identity, concentration, oxidation, contaminants and label accuracy.
• Fish-oil sources: Anchovy and/or sardine.
• Softgel gelatin sources: Tilapia and/or pangasius.
• Formulated without corn, dairy, egg, gluten, genetically modified ingredients, peanuts, sesame, shellfish, soy, tree nuts, wheat or yeast.
• Enteric-coated softgel.

Contains fish. This product is not appropriate for anyone with an allergy to fish or another listed ingredient.

Who Should Discuss Fish Oil With a Clinician?

Consult your healthcare professional before use if you:

• Take an anticoagulant or antiplatelet medication
• Have a bleeding disorder
• Are preparing for surgery or another invasive procedure
• Have a history of atrial fibrillation or another significant rhythm disorder
• Are pregnant or breastfeeding
• Use prescription omega-3 medication
• Are being treated for severely elevated triglycerides

Do not stop or replace a prescribed medication, including prescription omega-3 therapy, without guidance from the prescribing clinician.

Suggested Use

Take 1 enteric-coated softgel daily, preferably with a meal, or as directed by your healthcare professional.

At the suggested use, a 120-softgel bottle provides approximately a 120-day supply.

The HormoneSynergy® Perspective

Pure Omega 1300 EC is one of the more interesting omega-3 formulas because it combines a meaningful one-softgel dose with a delivery system supported by human pharmacokinetic research.*

That does not make it the correct fish oil for everyone. Someone who needs a substantially higher EPA or EPA-plus-DHA dose may require a different strategy. Someone who regularly eats fatty fish may need less supplemental omega-3. Someone with high triglycerides needs the reason for those triglycerides addressed, not simply another bottle of fish oil.

We view Pure Omega 1300 EC as a concentrated nutritional omega-3 option with good absorption characteristics, not as a shortcut around preventive cardiology, metabolic health, nutrition or prescribed treatment.

Clinical and Educational Resources

• Chevalier et al.: Monoglyceride, Ethyl Ester and Triglyceride Omega-3 Pharmacokinetics
• NIH Office of Dietary Supplements: Omega-3 Fatty Acids Fact Sheet

Frequently Asked Questions

How much EPA and DHA does one softgel provide?

One softgel provides 600 mg EPA and 260 mg DHA, for 860 mg of combined EPA and DHA.

What does “1300” mean?

It refers to 1,300 mg of MaxSimil® fish-oil concentrate in each softgel. It does not mean that the softgel contains 1,300 mg of combined EPA and DHA.

What is MaxSimil®?

MaxSimil® is an enzymatically produced monoglyceride fish-oil delivery system designed to improve EPA and DHA absorption compared with ethyl ester fish oil.*

Is the three-times-greater-absorption claim accurate?

The manufacturer describes MaxSimil® as providing three-times-greater EPA and DHA absorption than an equivalent ethyl ester fish oil.* Published human pharmacokinetic research supports improved absorption of monoglyceride omega-3s, although the size of the difference varies by the fatty acid, comparator, meal and outcome measured.

Is MaxSimil® better than triglyceride fish oil?

Not necessarily in every circumstance. In one crossover trial conducted with low-fat meals, monoglyceride omega-3s produced greater overall plasma omega-3 exposure. EPA exposure was approximately twice that of ethyl esters and similar to the triglyceride form. Product choice should also consider dose, quality, tolerance and the clinical goal.

Does this product lower triglycerides?

EPA and DHA can support healthy triglyceride metabolism and lower elevated triglyceride concentrations at clinically meaningful doses.* One softgel provides 860 mg of EPA plus DHA and should not be confused with prescription-dose omega-3 treatment for significant hypertriglyceridemia.

Is this the same as prescription fish oil?

No. Pure Omega 1300 EC is a dietary supplement. It is not equivalent to a prescription omega-3 product and should not replace prescribed therapy without medical guidance.

Does the enteric coating prevent fishy aftertaste?

The coating is designed to delay release beyond the stomach and may reduce fishy aftertaste for some users.* It cannot guarantee that every person will avoid burping, reflux or digestive discomfort.

Is it IFOS certified?

Yes. The current formula is listed as IFOS 5-Star certified for purity, potency and freshness.

What kind of fish does it contain?

The fish oil is sourced from anchovy and/or sardine. The softgel gelatin is sourced from tilapia and/or pangasius.

How should I take it?

Take 1 enteric-coated softgel daily, preferably with a meal, or as directed by your healthcare professional.

*Important Notice: Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Information provided is educational and should not replace personalized medical advice.

For best results, supplements should be used as part of a comprehensive health strategy including nutrition, exercise, restorative sleep, stress management, and appropriate medical evaluation when necessary.