Product Overview
Big Bold Health Microbiome Rejuvenate® is a three-part gut-support formula that brings together prebiotic nutrition, a clinically studied probiotic strain, and an algae-derived postbiotic. Each two-capsule serving provides 600 mg of sprouted Himalayan Tartary Buckwheat, 370 mg of BetaVia™ Complete beta glucans, 5 billion CFU of Lacticaseibacillus rhamnosus CRL 1505, plus quercetin and luteolin. The formula is designed to support microbiome health, intestinal resilience, healthy immune signaling, and the larger gut-immune relationship.*
Best For
- Adults looking for broader microbiome support than a probiotic alone*
- Supporting beneficial gut bacteria with both probiotic organisms and prebiotic nutrition*
- Supporting intestinal and gut-immune resilience*
- Increasing dietary exposure to Himalayan Tartary Buckwheat polyphenols*
- Adults interested in prebiotic, probiotic, and postbiotic support in one formula*
- Supporting microbiome health as part of a larger longevity strategy*
A Three-Part Approach to the Microbiome
Microbiome supplements are often placed into separate categories: probiotics add selected organisms, prebiotics provide substrates those organisms can use, and postbiotics provide microbial or microbial-derived components that can interact with the intestinal and immune environment.
Microbiome Rejuvenate® deliberately combines all three approaches.
The formula starts with HTB Activ™, Big Bold Health's sprouted Himalayan Tartary Buckwheat ingredient, as a source of prebiotic fiber and a diverse plant-polyphenol matrix.
It adds Lacticaseibacillus rhamnosus CRL 1505, a specific probiotic strain with human clinical research.
Finally, BetaVia™ Complete provides an algae-derived beta-glucan ingredient used as the formula's postbiotic component.
Quercetin and luteolin add another 100 mg of concentrated polyphenol support.
That combination is what makes Microbiome Rejuvenate® more interesting than a conventional high-CFU probiotic capsule. The emphasis is not simply on adding bacteria. It is on supporting the intestinal ecosystem from several directions at once.
What Each Two-Capsule Serving Provides
- Sprouted Organic Himalayan Tartary Buckwheat: 600 mg
- BetaVia™ Complete: 370 mg of beta-glucans from microalgae
- Lacticaseibacillus rhamnosus CRL 1505: 5 billion CFU
- Quercetin: 50 mg
- Luteolin: 50 mg
Serving size: 2 capsules
HTB Activ™: Prebiotic Fiber + Polyphenols
HTB Activ™ is Big Bold Health's proprietary sprouted Himalayan Tartary Buckwheat ingredient.
Himalayan Tartary Buckwheat is botanically a pseudocereal rather than wheat. It is particularly notable for its naturally diverse phytochemical profile, including rutin, quercetin, phenolic acids, and many other plant polyphenols.
Big Bold Health grows its HTB with U.S. farming partners, then sprouts, gently dries, and mills the seed. The sprouting step changes the plant's biochemistry as germination begins and increases production of a variety of naturally occurring protective compounds.
In Microbiome Rejuvenate®, HTB Activ™ contributes both plant polyphenols and prebiotic nutrition that can interact with the intestinal microbiome.*
Lacticaseibacillus rhamnosus CRL 1505
The probiotic in Microbiome Rejuvenate® is not a generic Lactobacillus blend. It is a specific strain: Lacticaseibacillus rhamnosus CRL 1505.
That distinction matters because probiotic research is strain-specific. Results from one strain of L. rhamnosus cannot automatically be transferred to every other strain carrying the same species name.
CRL 1505 has been studied for its interaction with mucosal immunity, intestinal signaling, and immune response. A two-capsule serving of Microbiome Rejuvenate® provides 5 billion CFU.
Human Research on CRL 1505
A randomized, double-blind, placebo-controlled clinical trial published in 2026 evaluated L. rhamnosus CRL 1505 in healthy adults over 12 weeks, followed by an additional four-week observation period.
The study found meaningful differences in several immune-related outcomes, including fewer total upper-respiratory episodes, shorter cumulative duration, more time without an episode, and less use of symptomatic medication among participants receiving the probiotic.
This is useful evidence because the trial evaluated the specific CRL 1505 strain rather than simply another member of the L. rhamnosus species.
The trial used 1 billion CFU per day as a stand-alone intervention. Microbiome Rejuvenate® provides 5 billion CFU of CRL 1505 within a multi-ingredient gut-support formula, so the study should be viewed as evidence for the strain rather than as a clinical trial of Microbiome Rejuvenate® itself.
Read the CRL 1505 randomized clinical trial
BetaVia™ Complete
BetaVia™ Complete adds a very different type of microbiome support.
It is derived from a proprietary strain of the microalga Euglena gracilis and naturally contains beta-1,3-glucan. Big Bold Health uses BetaVia™ Complete as the postbiotic component of Microbiome Rejuvenate®.
Beta-glucans can interact with innate immune pathways and have been studied for their effects on immune response and intestinal physiology.* BetaVia™ Complete itself has been evaluated in randomized, double-blind, placebo-controlled human research in healthy adults.
The combination with CRL 1505 creates an interesting division of labor: a live probiotic organism on one side and an algae-derived beta-glucan ingredient on the other, supported by HTB Activ™ as the food-derived polyphenol and prebiotic component.
Quercetin + Luteolin
Microbiome Rejuvenate® also contains 50 mg each of quercetin and luteolin.
Both are flavonoids found naturally in plant foods. Rather than functioning only as direct antioxidants, dietary polyphenols interact with cellular signaling and are also extensively metabolized by intestinal microorganisms.
This two-way relationship is one of the more interesting areas of microbiome nutrition: gut microbes transform polyphenols, while polyphenols and their metabolites can influence the microbial environment.
For a deeper look at this biology, see Polyphenols, Immunometabolism, and Longevity Medicine.
Why Prebiotics, Probiotics, and Postbiotics Are Different
The terminology can become unnecessarily complicated, but the basic distinctions are useful.
Prebiotics are substrates that selected microorganisms can use. Different fibers and plant compounds can influence different microbial populations and metabolic pathways.
Probiotics are live microorganisms that, when delivered in appropriate amounts, may provide a health benefit. Their effects depend heavily on the exact strain.
Postbiotics are preparations of inanimate microorganisms or their components that can interact with host physiology without requiring the organism to remain alive.
Microbiome Rejuvenate® brings these strategies together rather than assuming one category can do everything.
The Gut-Immune Connection
The intestine contains one of the body's largest interfaces between the outside environment and the immune system.
Food, microbes, microbial metabolites, intestinal cells, mucus, immune cells, bile acids, and signaling molecules are constantly interacting there. This is why microbiome health has implications well beyond bowel regularity or occasional digestive symptoms.
Microbial metabolites can participate in immune and metabolic signaling. Intestinal barrier integrity affects how the body interacts with bacterial products. Dietary fiber and polyphenols help shape the environment in which this occurs.
That broader physiology is why we consider the microbiome an important part of longevity medicine rather than an isolated digestive topic.
Explore the full system in our Gut Health, Microbiome, and Longevity Medicine resource.
Microbiome Health Is Bigger Than CFU Count
More bacteria on a label do not automatically make a better probiotic.
The strain matters. The clinical objective matters. Diet matters. Fiber intake matters. Medications, bowel function, sleep, movement, metabolic health, alcohol exposure, and recent antibiotic use all influence the intestinal environment.
That is one reason we like the construction of Microbiome Rejuvenate®. It does not rely on an enormous list of organisms simply to create a more impressive CFU number.
Instead, it uses one defined probiotic strain alongside prebiotic and postbiotic support, then adds polyphenols that interact with both the host and microbial metabolism.
How to Use Microbiome Rejuvenate®
Take 2 capsules daily with water, or use as directed by your healthcare professional.
Big Bold Health currently positions the product for ongoing daily use as part of a broader gut and immune-health strategy.*
Product Features
- 5 billion CFU of L. rhamnosus CRL 1505 per serving
- 600 mg sprouted organic Himalayan Tartary Buckwheat
- 370 mg BetaVia™ Complete
- 100 mg combined quercetin and luteolin
- Prebiotic + probiotic + postbiotic approach
- Grain-free
- Non-GMO Project Verified
- Third-party tested
- Ingredients supplied through GMP- and NSF-certified sources
- USA-produced
The HormoneSynergy® Perspective
There is no shortage of gut supplements built around huge organism counts, long strain lists, or vague promises to “reset” the microbiome.
Microbiome Rejuvenate® is more interesting because the formula has a clear structure.
HTB Activ™ provides food-derived polyphenols and prebiotic nutrition. CRL 1505 supplies a defined probiotic strain with human clinical research. BetaVia™ Complete adds an algae-derived beta-glucan postbiotic. Quercetin and luteolin broaden the polyphenol component.
That makes it a thoughtful option for someone looking beyond a probiotic-only strategy and toward a broader approach to microbiome and gut-immune support.*
It also fits well with our larger view of gut health: the goal is not simply to put more organisms into a capsule. The goal is to support the environment in which the intestinal ecosystem functions.
Frequently Asked Questions
Is Microbiome Rejuvenate® a probiotic?
Yes, but it is more than a probiotic. Each serving contains 5 billion CFU of Lacticaseibacillus rhamnosus CRL 1505 along with HTB Activ™ prebiotic nutrition and BetaVia™ Complete as a postbiotic component.
What probiotic strain is in Microbiome Rejuvenate®?
The formula contains Lacticaseibacillus rhamnosus CRL 1505, a defined probiotic strain with published human clinical research.
How many CFU does it provide?
Each two-capsule serving provides 5 billion CFU of L. rhamnosus CRL 1505.
What is BetaVia™ Complete?
BetaVia™ Complete is an ingredient derived from the microalga Euglena gracilis and naturally rich in beta-1,3-glucan. It is included as the postbiotic component of Microbiome Rejuvenate® and has been evaluated in human clinical research.
What is HTB Activ™?
HTB Activ™ is Big Bold Health's proprietary sprouted Himalayan Tartary Buckwheat ingredient. It provides a diverse matrix of plant polyphenols and prebiotic nutrition.
Does Microbiome Rejuvenate® contain quercetin?
Yes. Each serving provides 50 mg of quercetin along with 50 mg of luteolin.
How is this different from a conventional probiotic?
A conventional probiotic primarily supplies live microorganisms. Microbiome Rejuvenate® combines a defined probiotic strain with HTB Activ™ prebiotic nutrition, BetaVia™ Complete postbiotic support, and concentrated polyphenols.
How should I take Microbiome Rejuvenate®?
Take two capsules daily with water, or use as directed by your healthcare professional.
Is Himalayan Tartary Buckwheat wheat?
No. Despite its name, buckwheat is botanically unrelated to wheat. Himalayan Tartary Buckwheat is a pseudocereal and is naturally gluten-free.
If pregnant or nursing, taking prescription medication, immunocompromised, or managing a significant gastrointestinal or medical condition, discuss probiotic and supplement use with your healthcare professional. Individuals with a known buckwheat allergy should avoid products containing Himalayan Tartary Buckwheat.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.