The Best Supplements to Support GLP-1 Weight Loss: A Science-Backed Guide from HormoneSynergy® / RetzlerRx®

by Daniel Soule December 11, 2025

GLP-1 Weight Loss Support Supplements

GLP-1 medications like semaglutide and tirzepatide are powerful tools for fat loss and metabolic disease reversal. But the secret to sustainable success is not the medication alone—it’s the metabolic and microbiome foundation you build around it (and changing the lifestyle that contributed to the problem to begin with).

At HormoneSynergy® / RetzlerRx®, we specialize in a longevity-focused, science-driven approach that protects muscle mass, supports mitochondrial function, enhances gut resilience, and optimizes metabolic pathways during GLP-1 therapy.

Below is our clinician-curated guide to the most effective supplements for maximizing GLP-1 results—including Akkermansia, GLP-1 Probiotic PRO, GLP-1 Probiotic, Akkermansia 500, Metagenics® UltraFlora® Healthy Weight, Calocurb, Microbiome Labs Total Gut Resoration Kits, and targeted RetzlerRx® metabolic formulations.

Here is a list of GLP-1 weight loss supplements

1. Akkermansia: The Keystone Microbe for Glucose & Weight Regulation

Akkermansia muciniphila is a foundational gut bacteria associated with improved metabolism, gut barrier integrity, and inflammatory balance—three pillars of long-term GLP-1 success.

Pendulum Life Akkermansia

This retail-formula probiotic supports:

Gut barrier function
Appetite regulation
Healthy inflammatory response
Better metabolic flexibility during weight loss

Akkermansia 500 PRO (Pendulum PRO Line)

Akkermansia 500 is a higher-potency practitioner formulation ideal for:

Advanced metabolic dysfunction
GLP-1 patients with significant GI or metabolic issues
Faster microbiome rebalancing and support

For many GLP-1 patients, Akkermansia is a cornerstone of their microbiome strategy.

2. GLP-1 Probiotic & GLP-1 Probiotic PRO (Pendulum Life)

GLP-1 Probiotic

The standard GLP-1 Probiotic formula is designed to help:

Support GLP-1 production
Improve glycemic control
Modulate appetite and cravings
Enhance digestive comfort when gastric emptying slows

GLP-1 Probiotic PRO (Pendulum PRO Line)

GLP-1 Probiotic PRO is the practitioner-strength version, offering higher concentrations of GLP-1–modulating strains and deeper metabolic support.

GLP-1 Probiotic PRO is especially helpful for patients who:

Have insulin resistance or prediabetes
Experience GI distress on GLP-1 medications
Need a more aggressive microbiome-based metabolic strategy

Together, GLP-1 Probiotic and GLP-1 Probiotic PRO give us flexible tools to personalize support for different levels of metabolic need.

3. Metagenics® UltraFlora® Healthy Weight With Akkermansia

UltraFlora® Healthy Weight is a targeted metabolic probiotic that combines:

Akkermansia muciniphila
Bifidobacterium lactis B420™, one of the most studied strains for waist circumference and body fat reduction
Lactobacillus gasseri strains that support fat metabolism

Benefits may include:

Improved central fat loss and waist circumference
Enhanced appetite and satiety signaling
Reduced inflammation and better gut integrity
Support for metabolic rate during calorie restriction

UltraFlora® Healthy Weight pairs extremely well with Akkermansia and GLP-1 Probiotic PRO as part of a comprehensive microbiome strategy for GLP-1 weight loss.

4. Calocurb: Natural Appetite Regulation & Craving Control

Calocurb uses Amarasate®, a clinically validated bitter hops extract that activates the gut-brain satiety pathway.

Calocurb is particularly useful for patients who struggle with:

Evening snacking
Cravings under stress
Emotional or habitual eating patterns

By enhancing satiety and reducing cravings, Calocurb supports adherence to nutrition plans alongside GLP-1 medications.

5. RetzlerRx® Supplements That Integrate with GLP-1 Weight Loss

Our RetzlerRx® formulations are designed to complement GLP-1 therapy by addressing inflammation, detoxification, micronutrient adequacy, and muscle preservation.

Microbiome Labs Total Gut Restoration Kit

Support Microbiome Balance: MegaSporeBiotic™ introduces precision probiotic strains that help maintain a diverse and resilient gut ecosystem.
Promote Gut Barrier Integrity: MegaMucosa™ provides key nutrients to help protect and maintain the gut lining.
Fuel Beneficial Bacteria: MegaPre™ serves as a cutting-edge prebiotic, feeding the good bacteria to help them thrive.

RetzlerRx® Omega-3 (IFOS Certified)

Supports a healthy inflammatory response
Promotes metabolic flexibility and cardiovascular health

RetzlerRx® NAC + S-Acetyl Glutathione Support

Helps maintain antioxidant defenses during low-calorie phases
Supports liver detoxification and cellular resilience

RetzlerRx® Magnesium Glycinate UltraMag

Supports blood sugar regulation and insulin sensitivity
Improves muscle relaxation, bowel regularity, and sleep quality

MegaSporeBiotic® & Microbiome Labs GI Support

Enhances gut resilience and microbiome diversity
Helps reduce GI side effects associated with GLP-1 medications

SPMs (Specialized Pro-Resolving Mediators)

Support the natural resolution of inflammation
Enhance recovery and tissue repair during recomposition

Synergy Joint & Cartigenix

Support cartilage, joint comfort, and mobility as body composition shifts

Vascanox® Nitric Oxide Support

Supports vascular health and nitric oxide production
Improves exercise capacity and oxygen delivery

High-Quality Protein & Collagen Support for the Whole Body

Helps preserve lean muscle mass during rapid weight loss
Supports joints, connective tissue, and skin integrity

Together, these supplements create a robust foundation for healthy, sustainable GLP-1–based weight loss.

6. Why Gut Health Matters Even More During GLP-1 Therapy

GLP-1 medications slow gastric emptying and change how food moves through the GI tract. Without proper support, patients may experience:

Nausea or bloating
Constipation or altered bowel habits
Dysbiosis and microbiome imbalance
Reduced appetite leading to inadequate protein and micronutrient intake

This is why we emphasize Akkermansia, GLP-1 Probiotic, GLP-1 Probiotic PRO, UltraFlora® Healthy Weight, MegaSporeBiotic, magnesium, NAC, and glutathione as key tools for comfort, absorption, and long-term metabolic success.

7. The HormoneSynergy® Weight Loss for Longevity™ Approach

Unlike quick-fix weight loss programs, our focus is on healthspan—helping you live healthier, longer.

Our Weight Loss for Longevity™ program integrates:

GLP-1 medications when appropriate
Advanced diagnostics such as DEXA, SECA BIA, CIMT, and Cleerly CCTA
Comprehensive lab testing and risk assessment
Personalized nutrition, exercise, and sleep strategies
Targeted supplement protocols from RetzlerRx® and curated partner brands

Our goal is not just for you to lose weight—it’s to protect your muscle, brain, heart, and metabolic health for the long term.

Next Steps

If you’re currently using a GLP-1 medication or considering it and want a structured, longevity-focused plan, we invite you to learn more:

We work with patients locally in Portland and Lake Oswego, Oregon, and offer select services and products nationwide across the United States.