Synergy SPM | Specialized Pro-Resolving Marine Lipids

RetzlerRx® Synergy SPM provides an active fractionated marine lipid concentrate standardized to 18-HEPE, 17-HDHA, and 14-HDHA, omega-3-derived lipid mediators involved in the body’s natural pathways for resolving a normal inflammatory response.*

Each two-softgel serving provides 1 gram of fractionated marine lipid concentrate. Synergy SPM is designed for people looking for targeted nutritional support for joint comfort, physical recovery, healthy immune signaling, and tissue resilience.*

What Makes Synergy SPM Different?

EPA and DHA from conventional fish oil are important omega-3 fatty acids with established roles in cardiovascular, neurological, and cellular health. Synergy SPM is different. Its marine lipid concentrate is fractionated and standardized to three specific omega-3-derived mediators: 18-hydroxy-eicosapentaenoic acid (18-HEPE), 17-hydroxy-docosahexaenoic acid (17-HDHA), and 14-hydroxy-docosahexaenoic acid (14-HDHA).

These compounds are involved in biochemical pathways that contribute to the production and activity of specialized pro-resolving mediators. Resolution is an active part of the normal inflammatory response in which inflammatory signaling is brought toward completion and tissues move back toward balance.

This is different from simply trying to suppress inflammatory signaling. Synergy SPM is used as nutritional support for the body’s normal resolution and recovery processes.*

Standardized Pro-Resolving Marine Lipids

Each two-softgel serving provides:

• Active Fractionated Marine Lipid Concentrate — 1 g
• 18-HEPE — 18-hydroxy-eicosapentaenoic acid
• 17-HDHA — 17-hydroxy-docosahexaenoic acid
• 14-HDHA — 14-hydroxy-docosahexaenoic acid

The marine lipid concentrate is derived from fish oil from anchovy, sardine, and mackerel and includes mixed tocopherols as an antioxidant.

Contains fish.

Why These Three Mediators Matter

18-HEPE, 17-HDHA, and 14-HDHA are omega-3-derived lipid mediators associated with pathways involved in the resolution phase of a normal inflammatory response. Marine lipid concentrates standardized to these compounds have also been used in human clinical research examining physical discomfort, recovery, and joint function.

The research does not establish these compounds as treatments for inflammatory disease, nor does it mean that more mediators automatically produce better clinical results. Their value is that they provide a defined and measurable composition rather than relying solely on a general fish-oil concentration.

Synergy SPM and Fish Oil Serve Different Purposes

Traditional omega-3 supplements primarily provide EPA and DHA as foundational fatty acids. These nutrients remain important, and Synergy SPM is not intended to replace an omega-3 supplement when EPA and DHA supplementation is otherwise appropriate.

Synergy SPM provides a more targeted fractionated marine lipid concentrate standardized to compounds involved farther along omega-3-derived resolution pathways. Depending on the individual, an omega-3 supplement and Synergy SPM may be used for different nutritional purposes within the same broader plan.

How We Use SPM Support

At HormoneSynergy®, SPM support may be considered when joint comfort, physical recovery, inflammatory balance, or healthy aging is part of a broader clinical or nutritional strategy. It is generally used alongside the fundamentals that have a much larger influence on long-term health, including nutrition, exercise, muscle preservation, sleep, metabolic health, and appropriate medical care.

As with other RetzlerRx® products, the goal is not to add supplements simply because a biological pathway exists. The formulation is used when the ingredient profile and the reason for using it make sense for the individual.

Suggested Use

Take two softgels once daily, or as directed by your healthcare practitioner.

If you are pregnant, nursing, taking medications, have a fish allergy, or are being treated for a medical condition, discuss supplement use with your healthcare professional.

Learn More from HormoneSynergy®

• Specialized Pro-Resolving Mediators and Inflammation Resolution
• Omega-3 Fatty Acids: Brain, Heart, Inflammation, and Longevity
• The Practical Longevity Supplement Stack: What We Use and Why

Frequently Asked Questions

What are Specialized Pro-Resolving Mediators?

Specialized pro-resolving mediators, commonly abbreviated SPMs, are lipid signaling molecules involved in the active resolution phase of a normal inflammatory response. They are produced through pathways involving omega-3 fatty acids such as EPA and DHA.

What does Synergy SPM contain?

Each two-softgel serving provides 1 gram of active fractionated marine lipid concentrate standardized to 18-HEPE, 17-HDHA, and 14-HDHA.

What are 18-HEPE, 17-HDHA, and 14-HDHA?

They are omega-3-derived hydroxy fatty-acid mediators involved in biochemical pathways associated with specialized pro-resolving mediator production and normal inflammation resolution.

Is Synergy SPM the same as ordinary fish oil?

No. Conventional fish oil primarily supplies EPA and DHA. Synergy SPM uses a fractionated marine lipid concentrate standardized to 18-HEPE, 17-HDHA, and 14-HDHA. Fish oil and Synergy SPM may therefore serve different nutritional purposes.

Can I use Synergy SPM with an omega-3 supplement?

They may be used together when appropriate because they provide different marine-lipid components. Total supplement use should still be considered in the context of medications, health history, diet, and individual needs.

How do I take Synergy SPM?

Take two softgels once daily, or as directed by your healthcare practitioner.

Does Synergy SPM contain fish?

Yes. The marine lipid concentrate is derived from anchovy, sardine, and mackerel. People with fish allergies should not use the product without appropriate medical guidance.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.