Explore Dr. Retzler’s HormoneSynergy® Longevity Medicine Resource Library
Longevity Medicine
Cart

HormoneSynergy® Supplement Guide & Clinical Catalog

HormoneSynergy® Longevity Medicine
Evidence-Based Preventive Longevity Medicine
Updated September 2026

AI Overview: The HormoneSynergy® Supplement Guide organizes RetzlerRx® formulas and clinically selected professional supplements around the major systems involved in healthy aging, including metabolic health, cardiovascular health, gut and microbiome function, brain health, bone and muscle, hormone support, sleep, inflammation and foundational nutrient status. Supplements are one tool within a larger longevity medicine strategy, not a substitute for nutrition, exercise, testing or medical care.

The supplement market makes it easy to accumulate bottles and surprisingly difficult to answer a more basic question: what actually belongs in your plan?

HormoneSynergy® organizes supplements by clinical purpose rather than by trend, ingredient popularity or the number of claims that can fit on a label. A product may reasonably fit more than one category, but there should still be a clear reason for using it.

This page is our central supplement directory. It brings together RetzlerRx® formulas, selected HormoneSynergy® products and professional supplement lines used within our broader longevity medicine framework.

If your first question is not which product but whether you need a supplement at all, begin with our What Vitamins Should I Take? Evidence-Based Guide to Supplements, Nutrient Gaps, Testing & Safety.

One-Minute Read

There is no universal supplement stack for healthy aging. Diet, age, medications, medical history, hormone status, gastrointestinal function, body composition, activity level and laboratory findings can all change what may be useful.

Some supplements fill identifiable nutrient gaps. Others have evidence for a particular purpose even when a deficiency is not present. Creatine, omega-3 fatty acids and selected probiotics are examples where the reason for use may extend beyond correcting a traditional deficiency.

Quality matters, but a well-manufactured supplement is still unnecessary if there is no good reason to take it. Dose, formulation, interactions and duplication across products matter as well.

Use this page to browse supplements by clinical category. For a searchable list of active HormoneSynergy® and RetzlerRx® products, use the HormoneSynergy® Supplement Catalog. For individualized decisions, review the entire supplement list alongside medications, diet, goals and relevant medical information.

Professional Supplement Catalogs

HormoneSynergy® also offers selected professional supplement lines. These catalogs are separate from the clinical categories below and provide a more complete brand-level inventory.

Metabolic Health

Metabolic health includes much more than glucose. Insulin signaling, visceral fat, appetite regulation, skeletal muscle, triglycerides, sleep and activity all contribute to metabolic resilience. Supplements in this category should sit alongside nutrition, resistance training, sleep and appropriate metabolic assessment.

For the larger clinical framework, see Metabolic Health and Longevity Medicine.

Cardiovascular & Omega-3 Support

Preventive cardiology begins with risk assessment, not supplements. ApoB, Lipoprotein(a), blood pressure, metabolic health, smoking, kidney function, family history and direct assessment of plaque when appropriate generally matter more than adding a generic “heart health” formula.

For context, see Preventive Cardiology and Silent Heart Disease Detection.

Gut Health, Histamine & Microbiome

The gut microbiome interacts with immune signaling, nutrient absorption, inflammatory tone, metabolic physiology and the intestinal barrier. “Probiotic” is not one treatment, and different organisms, strains, fibers and formulations serve different purposes.

See our Gut Health, Microbiome, and Longevity Medicine guide for the broader framework.

Polyphenols, Food Matrix Nutrition & Immunometabolism

Whole-food compounds, polyphenols, fibers, marine lipids and microbiome-directed nutrients can influence multiple systems at once. They are best understood as part of nutrition physiology rather than as isolated “superfood” cures.

For deeper context, read Polyphenols, Immunometabolism, and Longevity Medicine.

Brain, Mood & Nervous System

Brain health is influenced by vascular health, sleep, insulin sensitivity, hearing, inflammation, hormones, mental health, nutrient status and physical activity. Supplements should be placed inside that larger context.

Explore Brain Health & Cognitive Longevity.

Bone, Muscle & Body Composition

Muscle and bone are central to healthy aging. Protein intake, resistance training, hormone status, vitamin D, calcium adequacy and body composition should be evaluated together rather than treating each as a separate supplement problem.

Related HormoneSynergy® resources:

Methylation, Antioxidants & Glutathione

Methylation and antioxidant biology are real biochemical systems, but they should not be reduced to generic “detox” marketing. Folate status, B vitamins, homocysteine metabolism, glutathione, liver function, oxidative stress and total exposure all require context.

Hormone Support

Hormone-related supplements require more caution than general nutrients. DHEA, pregnenolone and formulas affecting estrogen or androgen pathways can interact with medications, hormone therapy, cancer history and individual endocrine physiology.

For the larger clinical framework, see Hormone Transitions: Perimenopause, Menopause & Andropause.

Immune & Inflammation

Inflammation is not simply something to suppress. Appropriate immune signaling and inflammation resolution are part of normal physiology. Sleep, metabolic health, nutrient status, gut integrity and the underlying cause of inflammatory signaling matter.

See Inflammation and Longevity Medicine.

Sleep, Stress & Recovery

Sleep affects glucose regulation, appetite, blood pressure, hormone signaling, memory, immune resilience and recovery. A sleep supplement should support a larger sleep strategy rather than substitute for identifying insomnia, sleep apnea, circadian disruption or another underlying problem.

See Sleep and Recovery in Longevity Medicine.

Foundational Nutrients

Foundational nutrients are often less exciting than the newest longevity compound, but correcting genuine nutritional gaps can matter more than adding novelty to an already crowded supplement regimen.

Before adding more supplements, review our evidence-based vitamin and supplement guide, including testing, nutrient gaps, interactions and the problem of supplement stacking.

How to Use This Supplement Guide

This page is a directory, not a prescription. A supplement may appear relevant because of a symptom or health goal without being necessary, appropriate or safe for a particular person.

Before adding a supplement, consider:

  • Why are you taking it?
  • Is there evidence for that specific use?
  • Could food meet the same nutritional need?
  • Would testing change the decision?
  • Does it duplicate something already in your regimen?
  • Could it interact with a prescription medication or medical condition?
  • Is the dose appropriate?
  • How will you know whether it is helping?

For a deeper framework, read What Vitamins Should I Take? and Medicine, Not Marketing.

Frequently Asked Questions

Is this the complete HormoneSynergy® supplement catalog?

This page is the primary clinical directory for HormoneSynergy® and RetzlerRx® supplements. For a searchable inventory of active products, use the HormoneSynergy® Supplement Catalog. Separate professional catalogs are also available for Designs for Health®, Metagenics®, XYMOGEN®, Researched Nutritionals®, Microbiome Labs® and NutriDyn®.

Are these supplements meant to replace medical care?

No. Supplements are not a replacement for medical evaluation, diagnosis, prescription medication, nutrition, sleep, exercise or appropriate testing. They may serve as one layer within a broader health or longevity strategy.

Why are supplements organized by clinical system?

Metabolism, cardiovascular risk, gut health, hormones, inflammation, sleep, brain health and body composition are interconnected. Organizing products by clinical context makes it easier to understand why a product might be used rather than treating supplements as isolated ingredients.

Can a supplement belong to more than one category?

Yes. Omega-3 fatty acids may be relevant to cardiovascular health and inflammation. Magnesium may be considered in foundational nutrition, nervous-system support and sleep. Creatine intersects muscle, body composition and healthy aging. Category placement is a navigation tool rather than a claim that a product affects only one system.

Should everyone take a multivitamin or daily supplement stack?

No. Some people benefit from selected supplements while others can meet most nutritional requirements through food. Diet, age, medications, medical history, absorption, life stage and laboratory findings can all change the answer.

How do I know which vitamins or supplements I actually need?

Start with the purpose. Review your diet, existing supplements, medications, health history and whether laboratory testing would change the decision. Our What Vitamins Should I Take? guide provides a more detailed framework.

Medical Disclaimer

This page is provided for educational purposes and is not intended to diagnose, treat, cure or prevent disease, nor does it establish a physician-patient relationship. Supplements can interact with medications, medical conditions, surgery and laboratory testing. Discuss supplementation with an appropriate healthcare professional when relevant to your medical care.

*These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure or prevent any disease.

HormoneSynergy® Longevity Medicine
Medicine, Not Marketing.
Portland • Lake Oswego • USA