RetzlerRx® Systemic Enzyme Complex is a concentrated proteolytic enzyme formula designed for use between meals. It combines two branded enzyme preparations, Nattozimes® and Serrazimes®, to provide targeted support for healthy circulation, normal protein-clearing processes, inflammatory balance, and physical recovery.*
Unlike ordinary digestive enzymes taken with food, systemic enzyme formulas are used on an empty stomach. This allows the enzymes to be used as part of a broader strategy for circulatory wellness, tissue recovery, and healthy aging rather than primarily for meal digestion.*
- Adults seeking systemic proteolytic enzyme support*
- Individuals interested in healthy circulation and fibrin balance*
- People seeking nutritional support for a balanced inflammatory response*
- Active adults looking to support tissue recovery and mobility*
- Those incorporating enzyme support into a broader cardiovascular and longevity strategy*
What Each Capsule Provides
- Nattozimes®: 129 mg, providing 4,516 FU of exo/endo protease activity
- Serrazimes®: 33 mg, providing 20,000 units of exo/endo protease activity
- Serving size: One capsule
- Supply: 120 capsules
Enzyme activity units provide a more meaningful description of proteolytic potency than ingredient weight alone. Each capsule supplies clearly measured activity from both branded enzyme preparations.
Why Systemic Enzymes?
Proteolytic enzymes break proteins into smaller peptides and amino acids. When taken with food, they primarily assist with dietary protein digestion. When taken between meals, they are used as systemic enzymes to support protein-clearing pathways, healthy circulation, inflammatory balance, and recovery.*
Systemic enzyme support may be considered when the goal extends beyond digestion and includes maintaining healthy tissue function, vascular wellness, mobility, and resilience following physical activity.*
Nattozimes®
Nattozimes® is a branded exo/endo protease preparation derived from Aspergillus oryzae. Each capsule provides 4,516 fibrinolytic units of Nattozimes® activity.
Nattozimes® is included to support normal fibrin-management pathways, healthy blood flow, and circulatory wellness.* Fibrin is a natural protein involved in clot formation and tissue repair, and the body continuously regulates its formation and breakdown.
Supporting this natural balance may be useful within a broader strategy focused on cardiovascular function, microcirculation, activity, and healthy aging.*
Serrazimes®
Serrazimes® is a branded proteolytic enzyme preparation derived from Aspergillus melleus. Each capsule provides 20,000 units of exo/endo protease activity.
Serrazimes® is formulated to support normal protein breakdown, a balanced inflammatory response, tissue recovery, and comfortable mobility.* It complements the circulatory focus of Nattozimes® by broadening the formula’s proteolytic enzyme activity.*
Two Complementary Enzyme Preparations
Nattozimes® and Serrazimes® provide different but complementary forms of proteolytic activity. Together, they create a broader systemic enzyme formula than either ingredient would provide alone.*
- Nattozimes®: supports fibrin balance, healthy circulation, and vascular wellness*
- Serrazimes®: supports protein-clearing pathways, inflammatory balance, and tissue recovery*
- Combined formula: provides comprehensive systemic proteolytic enzyme support in one daily capsule*
An Important Ingredient Distinction
Nattozimes® is a fungal-derived protease preparation from Aspergillus oryzae; it is not nattokinase extracted from fermented soy. Serrazimes® is derived from Aspergillus melleus; it is not serrapeptase or a silkworm-derived ingredient.
These distinctions are important when comparing formulas. RetzlerRx® Systemic Enzyme Complex should be evaluated according to the specific ingredients and measured enzyme activity listed on its label.
Circulation and Fibrin Balance
Healthy circulation depends on multiple systems working together, including vascular tone, endothelial function, platelet activity, coagulation, fibrinolysis, metabolic health, and physical movement.
Systemic Enzyme Complex is designed to support the body’s normal fibrin-regulating processes and the maintenance of healthy blood flow.* It may be considered as supplemental support within a comprehensive cardiovascular wellness plan that also addresses blood pressure, lipids, glucose regulation, exercise, sleep, nutrition, and body composition.*
Inflammatory Balance and Recovery
Exercise, normal tissue remodeling, aging, and everyday physical stress all involve carefully regulated inflammatory and protein-clearing processes.
The proteolytic activity supplied by Nattozimes® and Serrazimes® may help support a healthy inflammatory response, normal tissue recovery, and comfortable movement.* This makes the formula relevant not only to circulatory wellness but also to individuals focused on maintaining physical function and resilience.*
How This Fits Into Longevity Medicine
Circulation and recovery influence nearly every aspect of healthy aging. Tissues depend on consistent delivery of oxygen and nutrients, while the body must also manage normal inflammatory signals and tissue remodeling.
RetzlerRx® Systemic Enzyme Complex may be selected as an adjunctive supplement for adults seeking additional support in these areas.* It works best as part of a broader longevity strategy that includes:
- Regular cardiovascular and resistance exercise
- Healthy blood pressure and lipid management
- Metabolic optimization
- Anti-inflammatory nutrition
- Restorative sleep and recovery
- Appropriate cardiovascular testing and medical care
Suggested Use
Take one capsule daily on an empty stomach, or use as directed by your healthcare professional.
Taking the formula away from meals helps distinguish systemic enzyme use from ordinary digestive-enzyme supplementation.*
Other Ingredients
Maltodextrin, beet root fiber, capsule (hypromellose and water), microcrystalline cellulose, medium-chain triglycerides, and magnesium stearate.
The current label identifies fungal sources for both active enzyme preparations and does not list soy as an ingredient.
Safety and Medication Considerations
Consult your healthcare professional before use if you take anticoagulant or antiplatelet medication, have a bleeding or clotting disorder, are pregnant or breastfeeding, or are preparing for surgery, dental work, or another invasive procedure. This supplement should not replace prescribed anticoagulation, antiplatelet therapy, or other cardiovascular treatment.
The HormoneSynergy® Perspective
RetzlerRx® Systemic Enzyme Complex offers a convenient way to incorporate two complementary proteolytic enzyme preparations into a daily longevity strategy.* The clearly stated enzyme activity, once-daily dosing, and combination of Nattozimes® and Serrazimes® make it a practical option for adults seeking circulatory, fibrin-balance, inflammatory-response, and recovery support.*
As with all supplements, the value depends on selecting the right product for the right person. Systemic enzymes are best used in support of measurable cardiovascular health, regular movement, sound nutrition, restorative sleep, and appropriate medical care.
Related HormoneSynergy® Resources
Frequently Asked Questions
What does RetzlerRx® Systemic Enzyme Complex support?
It is formulated to support systemic proteolytic enzyme activity, healthy circulation, fibrin balance, a normal inflammatory response, and tissue recovery.*
What are Nattozimes® and Serrazimes®?
They are branded fungal-derived protease preparations that provide complementary forms of systemic enzyme activity.*
Is Nattozimes® the same as nattokinase?
No. Nattozimes® is derived from Aspergillus oryzae. Nattokinase is a different enzyme traditionally produced during the bacterial fermentation of soybeans.
Is Serrazimes® the same as serrapeptase?
No. Serrazimes® is derived from Aspergillus melleus. Serrapeptase, also called serratiopeptidase, is a different enzyme.
Why should systemic enzymes be taken on an empty stomach?
Taking them away from meals is intended to support systemic enzyme use rather than primarily assisting with the digestion of dietary protein.*
Can this product be taken with blood-thinning medication?
Consult the prescribing healthcare professional before combining it with anticoagulant or antiplatelet medication.
How should I take Systemic Enzyme Complex?
Take one capsule daily on an empty stomach, or use as directed by your healthcare professional.
*Important Notice: Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Information provided is educational and should not replace personalized medical advice.
For best results, supplements should be used as part of a comprehensive health strategy including nutrition, exercise, restorative sleep, stress management, and appropriate medical evaluation when necessary.